Metal-Free, Acid-Promoted Synthesis of Imidazole Derivatives via a Multicomponent Reaction

被引：78
作者：
Chen, Chung-Yu [3 ]
Hu, Wan-Ping [2 ]
Yan, Pi-Cheng [1 ]
Senadi, Gopal Chandru [1 ]
Wang, Jeh-Jeng [1 ]
机构：
[1] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung, Taiwan
[2] Kaohsiung Med Univ, Dept Biotechnol, Kaohsiung, Taiwan
[3] Kaohsiung Med Univ, Dept Pharm, Kaohsiung, Taiwan
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 24期
关键词：
ONE-POT SYNTHESIS; SUBSTITUTED IMIDAZOLES; EFFICIENT SYNTHESIS; ALKALOIDS; ALDEHYDES; CATALYST; ALKYNES; LIGAND; PROBE;
D O I：
10.1021/ol402892z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An expedient and metal-free synthetic route has been developed for the construction of tri- and tetrasubstituted imidazole derivatives via acid promoted multicomponent reaction methodology. The reaction proceeded smoothly with a range of functionalities to produce the imidazole scaffolds in good to excellent yields.
引用
收藏
页码：6116 / 6119
页数：4
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