Metal-Free, Acid-Promoted Synthesis of Imidazole Derivatives via a Multicomponent Reaction

被引：79

作者：

Chen, Chung-Yu ^{[3
]}

Hu, Wan-Ping ^{[2
]}

Yan, Pi-Cheng ^{[1
]}

Senadi, Gopal Chandru ^{[1
]}

Wang, Jeh-Jeng ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung, Taiwan

[2] Kaohsiung Med Univ, Dept Biotechnol, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ, Dept Pharm, Kaohsiung, Taiwan

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 24期

关键词：

ONE-POT SYNTHESIS; SUBSTITUTED IMIDAZOLES; EFFICIENT SYNTHESIS; ALKALOIDS; ALDEHYDES; CATALYST; ALKYNES; LIGAND; PROBE;

D O I：

10.1021/ol402892z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An expedient and metal-free synthetic route has been developed for the construction of tri- and tetrasubstituted imidazole derivatives via acid promoted multicomponent reaction methodology. The reaction proceeded smoothly with a range of functionalities to produce the imidazole scaffolds in good to excellent yields.

引用

页码：6116 / 6119

页数：4

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