Role of TH17 cytokines in the control of colorectal cancer

被引：111
作者：
De Simone, Veronica [1 ]
Pallone, Francesco [1 ]
Monteleone, Giovanni [1 ]
Stolfi, Carmine [1 ]
机构：
[1] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 12期
关键词：
anti-cytokine therapy; colitis-associated colon cancer; IL-17A; IL-17F; IL-21; IL-22; inflammation; NF kappa B; STAT3; T(H)17 cells; ROR-GAMMA-T; COLON-CANCER; PROMOTES ANGIOGENESIS; TUMOR-GROWTH; TGF-BETA; CELLS; DIFFERENTIATION; COLITIS; IL-22; INTERLEUKIN-21;
D O I：
10.4161/onci.26617
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immune/inflammatory cells infiltrate almost all human solid tumors and affect all stages of carcinogenesis as they produce different cytokine subsets. The overproduction of T(H)17 cytokines marks the early stages of colorectal carcinoma (CRC) and negatively influences the prognosis of CRC patients. Studies with murine models of CRC have delineated the mechanisms by which T(H)17 cytokines, notably, interleukin (IL)-17A, IL-17F, IL-21, and IL-22, regulate oncogenesis and tumor progression, paving the way to the development of novel anticancer drugs. In this review article, we discuss experimental data supporting the role of T(H)17 cytokines in the modulation of colorectal tumorigenesis.
引用
收藏
页数：6
相关论文
共 64 条
[1]   Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells [J].
Acosta-Rodriguez, Eva V. ;
Napolitani, Giorgio ;
Lanzavecchia, Antonio ;
Sallusto, Federica .
NATURE IMMUNOLOGY, 2007, 8 (09) :942-949
[2]   Interleukin-6 and cachexia in ApcMin/+ mice [J].
Baltgalvis, Kristen A. ;
Berger, Franklin G. ;
Pena, Maria Marjorette O. ;
Davis, J. Mark ;
Muga, Stephanie J. ;
Carson, James A. .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2008, 294 (02) :R393-R401
[3]   TGF-β suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling [J].
Becker, C ;
Fantini, MC ;
Schramm, C ;
Lehr, HA ;
Wirtz, S ;
Nikolaev, A ;
Burg, J ;
Strand, S ;
Kiesslich, R ;
Huber, S ;
Ito, H ;
Nishimoto, N ;
Yoshizaki, K ;
Nishimoto, N ;
Galle, PR ;
Blessing, M ;
Rose-John, S ;
Neurath, MF .
IMMUNITY, 2004, 21 (04) :491-501
[4]  
Bernstein CN, 2001, CANCER-AM CANCER SOC, V91, P854, DOI 10.1002/1097-0142(20010215)91:4<854::AID-CNCR1073>3.0.CO
[5]  
2-Z
[6]   Expression of RORγt Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer [J].
Blatner, Nichole R. ;
Mulcahy, Mary F. ;
Dennis, Kristen L. ;
Scholtens, Denise ;
Bentrem, David J. ;
Phillips, Joseph D. ;
Ham, Soo ;
Sandall, Barry P. ;
Khan, Mohammad W. ;
Mahvi, David M. ;
Halverson, Amy L. ;
Stryker, Steven J. ;
Boller, Anne-Marie ;
Singal, Ashima ;
Sneed, Rebekka K. ;
Sarraj, Bara ;
Ansari, Mohammed Javeed ;
Oft, Martin ;
Iwakura, Yoichiro ;
Zhou, Liang ;
Bonertz, Andreas ;
Beckhove, Philipp ;
Gounari, Fotini ;
Khazaie, Khashayarsha .
SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (164)
[7]   Worldwide Variations in Colorectal Cancer [J].
Center, Melissa M. ;
Jemal, Ahmedin ;
Smith, Robert A. ;
Ward, Elizabeth .
CA-A CANCER JOURNAL FOR CLINICIANS, 2009, 59 (06) :366-378
[8]   Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis [J].
Chae, Wook-Jin ;
Gibson, Thomas F. ;
Zelterman, Daniel ;
Hao, Liming ;
Henegariu, Octavian ;
Bothwell, Alfred L. M. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (12) :5540-5544
[9]   IL-17A in the tumor microenvironment of the human colorectal adenoma-carcinoma sequence [J].
Cui, Guanglin ;
Yuan, Aping ;
Goll, Rasmus ;
Florholmen, Jon .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2012, 47 (11) :1304-1312
[10]   Interleukin-26: An IL-10-related cytokine produced by Th17 cells [J].
Donnelly, Raymond P. ;
Sheikh, Faruk ;
Dickensheets, Harold ;
Savan, Ram ;
Young, Howard A. ;
Walter, Mark R. .
CYTOKINE & GROWTH FACTOR REVIEWS, 2010, 21 (05) :393-401
1234567