Photosensitizer Loaded Nano-Graphene for Multimodality Imaging Guided Tumor Photodynamic Therapy

被引：180

作者：

Rong, Pengfei ^{[1
,2
]}

Yang, Kai ^{[2
,3
]}

Srivastan, Avinash ^{[2
]}

Kiesewetter, Dale O. ^{[2
]}

Yue, Xuyi ^{[2
,4
]}

Wang, Fu ^{[2
]}

Nie, Liming ^{[2
]}

Bhirde, Ashwinkumar ^{[2
]}

Wang, Zhe ^{[2
]}

Liu, Zhuang

Niu, Gang ^{[2
]}

Wang, Wei ^{[1
]}

Chen, Xiaoyuan ^{[2
]}

机构：

[1] Cent S Univ, Xiangya Hosp 3, Dept Radiol, Changsha 410013, Hunan, Peoples R China

[2] NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA

[3] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China

[4] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Fujian, Peoples R China

来源：

THERANOSTICS | 2014年 / 4卷 / 03期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

Graphene oxide; HPPH; photodynamic therapy; positron emission tomography; optical imaging; IN-VIVO; PHOTOTHERMAL THERAPY; DRUG-DELIVERY; PHTHALOCYANINE TETRASULFONATE; BIOMEDICAL APPLICATIONS; CANCER; OXIDE; EFFICACY; MICE; HPPH;

D O I：

10.7150/thno.8070

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Graphene, a 2-dimensional carbon nanomaterial, has attracted wide attention in biomedical applications, owing to its intrinsic physical and chemical properties. In this work, a photosensitizer molecule, 2-(I-hexyloxyethyl)-2-devinyl pyropheophorbide-alpha (HPPH or Photochlor (R)), is loaded onto polyethylene glycol (PEG)-functionalized graphene oxide (GO) via supramolecular Pi-Pi stacking. The obtained GO-PEG-HPPH complex shows high HPPH loading efficiency. The in vivo distribution and delivery were tracked by fluorescence imaging as well as positron emission tomography (PET) after radiolabeling of HPPH with Cu-64. Compared with free HPPH, GO-PEG-HPPH offers dramatically improved photodynamic cancer cell killing efficacy due to the increased tumor delivery of HPPH. Our study identifies a role for graphene as a carrier of PDT agents to improve PDT efficacy and increase long-term survival following treatment.

引用

页码：229 / 239

页数：11

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