Synthesis and electrochemical characterization of nanostructured magnetic molecularly imprinted polymers for 17-β-Estradiol determination

被引：110

作者：

Lahcen, Abdellatif Ait ^{[1
,2
]}

Baleg, Abd Almonam ^{[1
]}

Baker, Priscilla ^{[1
]}

Iwuoha, Emmanuel ^{[1
]}

Amine, Aziz ^{[2
]}

机构：

[1] Univ Western Cape, Sensor Lab, Dept Chem, ZA-7535 Bellville, South Africa

[2] Hassan II Univ Casablanca, Fac Sci & Tech, Lab Genie Proc & Environm, BP 146, Mohammadia, Morocco

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2017年 / 241卷

关键词：

17-beta-Estradiol; Molecularly imprinted polymers; Magnetite nanoparticles; Square - wave voltammetry; Screen printed carbon electrode; GRAPHENE OXIDE; NANOPARTICLES; SENSOR; NANOCOMPOSITE; SEPARATION; TEMPLATE; BREAST; WATER; UV;

D O I：

10.1016/j.snb.2016.10.132

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The authors report the synthesis, characterization and electrochemical study of a nanostructured magnetic molecularly imprinted polymer (Fe3O4-MIP) for the determination of 17-beta-Estradiol (17-beta-E2). The synthesized magnetic nanoparticles (Fe3O4-NPs) and Fe3O4-MIP were investigated using High Resolution Transmission Electron Microscopy (HRTEM), High Resolution Scanning Electron Microscopy (HRSEM), X-Ray Diffraction (XRD) and Fourrier Transform Infrared spectroscopy (FT-IR) as characterization techniques. The electrochemical characterization was studied by cyclic voltammetry and electrochemical impedance spectroscopy Several important parameters controlling the performance of the Fe3O4-MIP based sensor such as the choice of electrochemical analysis technique, the frequency, the effect of pH and the incubation time were investigated. Under the optimal conditions, the oxidation peak current was linearly related to 17-beta-E2 concentration in the range of 0.05-10 mu M. The Fe3O4-MIP based sensor amplifies the oxidation current in square-wave voltammetric measurements which allows reaching 20 nM as detection limit. Furthermore, the Fe3O4-MIP sensing system exhibits a high selectivity towards 17-beta-E2 and was applied successfully for its determination in river water samples. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：698 / 705

页数：8

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