A New Approach for the Synthesis of 6,7-Dihydro-5H-Cyclopenta[b]pyridine

被引：1

作者：

Zhou, Jinhua ^{[1
]}

Gao, Haili ^{[1
]}

Sun, Hanzhou ^{[1
]}

Wu, Yuxiong ^{[1
]}

机构：

[1] Cent South Univ Forestry Technol, Inst Appl Chem, Changsha 410004, Hunan, Peoples R China

来源：

ADVANCES IN CHEMICAL, MATERIAL AND METALLURGICAL ENGINEERING, PTS 1-5 | 2013年 / 634-638卷

关键词：

6,7-Dihydro-5H-Cyclopenta[b]pyridine; Vilsmeier reaction; Cefpirome; Synthesis;

D O I：

10.4028/www.scientific.net/AMR.634-638.1211

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

A new practical and efficient route was developed for the synthesis of 6,7-dihydro-5H-cyclopenta[b]pyridine, which is a key intermediate of cefpirome. Leading to the formation of the corresponding product, nucleophilic addition, acetylization, Vilsmeier cyclization reaction and dechlorination were employed under mild reaction conditions by using commercially available cyclopentanone and benzylamine as raw materials. The total yield of this newly developed synthetic route for the target product was 43.15% with 99.7% of purity (HPLC). The structure of target molecular was confirmed by LC-MS and H-1 NMR spectrum.

引用

页码：1211 / 1214

页数：4

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