Communication between viruses guides lysis-lysogeny decisions

被引:404
作者
Erez, Zohar [1 ]
Steinberger-Levy, Ida [1 ,2 ]
Shamir, Maya [1 ]
Doron, Shany [1 ]
Stokar-Avihail, Avigail [1 ]
Peleg, Yoav [3 ]
Melamed, Sarah [1 ]
Leavitt, Azita [1 ]
Savidor, Alon [4 ]
Albeck, Shira [3 ]
Amitai, Gil [1 ]
Sorek, Rotem [1 ]
机构
[1] Weizmann Inst Sci, Dept Mol Genet, IL-7610001 Rehovot, Israel
[2] Israel Inst Biol Res, Dept Biochem & Mol Genet, Ness Ziona, Israel
[3] Weizmann Inst Sci, Fac Biochem, ISPC, IL-7610001 Rehovot, Israel
[4] Weizmann Inst Sci, Nancy & Stephen Grand Israel Natl Ctr Personalize, de Botton Inst Prot Profiling, IL-7610001 Rehovot, Israel
基金
以色列科学基金会; 欧洲研究理事会;
关键词
BACILLUS-SUBTILIS; BACTERIA; MECHANISM; INFECTION; RECEPTOR; COMPLEX; SYSTEM; GENE; PLCR;
D O I
10.1038/nature21049
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Temperate viruses can become dormant in their host cells, a process called lysogeny. In every infection, such viruses decide between the lytic and the lysogenic cycles, that is, whether to replicate and lyse their host or to lysogenize and keep the host viable. Here we show that viruses (phages) of the SPbeta group use a small-molecule communication system to coordinate lysis-lysogeny decisions. During infection of its Bacillus host cell, the phage produces a six aminoacids-long communication peptide that is released into the medium. In subsequent infections, progeny phages measure the concentration of this peptide and lysogenize if the concentration is sufficiently high. We found that different phages encode different versions of the communication peptide, demonstrating a phage-specific peptide communication code for lysogeny decisions. We term this communication system the 'arbitrium' system, and further show that it is encoded by three phage genes: aimP, which produces the peptide; aimR, the intracellular peptide receptor; and aimX, a negative regulator of lysogeny. The arbitrium system enables a descendant phage to 'communicate' with its predecessors, that is, to estimate the amount of recent previous infections and hence decide whether to employ the lytic or lysogenic cycle.
引用
收藏
页码:488 / 493
页数:6
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