Synthesis, Antimicrobial and Anticancer Evaluations of Novel Thiazoles Incorporated Diphenyl Sulfone Moiety

被引：18
作者：
Shaaban, Mohamed R. [1 ,2 ]
Farghaly, Thoraya A. [1 ,2 ]
Alsaedi, Amani M. R. [2 ]
机构：
[1] Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt
[2] Umm Al Qura Univ, Fac Appl Sci, Dept Chem, Makkah Al Mukarramah, Saudi Arabia
来源：
POLYCYCLIC AROMATIC COMPOUNDS | 2022年 / 42卷 / 05期
关键词：
Antimicrobial activity; phenyl sulfones; thiazoles; thiosemicarbazone; α -halocarbonyl compounds; TAUTOMERIC STRUCTURE; DERIVATIVES;
D O I：
10.1080/10406638.2020.1837887
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel series of thiazoles incorporated phenylsulfonyl group have been designed and synthesized from the treatment of N-(1-(4-(phenylsulfonyl)phenyl)ethylidene)hydrazine carbothioamide with various types of alpha-halocarbonyl compounds in one-pot reaction strategy under microwaves irradiations. Studying all possible spectral data for the prepared compounds were proved their structure as well as the suggested mechanism of their reactions. The results of antimicrobial activity of some selected derivatives proved their potency in which some derivatives showed activity exceeded the activity of the reference drugs. In addition, selected derivatives were investigated for their anticancer activities against HepG-2 and HCT-116 cell lines to shed some light on the anticancer activity of the newly synthesized thiazole derivatives. One of the tested thiazole derivatives showed good activity in comparison with doxorubicin reference.
引用
收藏
页码：2521 / 2537
页数：17
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