Midlife cardiovascular health and 20-year cognitive decline: Atherosclerosis Risk in Communities Study results

被引：67

作者：

Gonzalez, Hector M. ^{[1
,2
]}

Tarraf, Wassim ^{[3
]}

Harrison, Kimystian ^{[4
]}

Windham, B. Gwen ^{[5
]}

Tingle, Jonathan ^{[6
]}

Alonso, Alvaro ^{[7
]}

Griswold, Michael ^{[6
]}

Heiss, Gerardo ^{[8
]}

Knopman, David ^{[9
]}

Mosley, Thomas H. ^{[5
,10
]}

机构：

[1] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA

[2] Univ Calif San Diego, Shiley Marcos Alzheimers Dis Res Ctr, San Diego, CA 92103 USA

[3] Wayne State Univ, Inst Gerontol, Dept Healthcare Sci, Detroit, MI 48202 USA

[4] Univ Mississippi, Med Ctr, Sch Med, Jackson, MS 39216 USA

[5] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA

[6] Univ Mississippi, Med Ctr, JD Bower Sch Populat Hlth, Dept Data Sci, Jackson, MS 39216 USA

[7] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA

[8] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA

[9] Mayo Clin, Dept Neurol, Rochester, MN USA

[10] Univ Mississippi, Med Ctr, Memory Impairment & Neurodegenerat Dementia MIND, Jackson, MS 39216 USA

来源：

ALZHEIMERS & DEMENTIA | 2018年 / 14卷 / 05期

关键词：

Epidemiology; Cognition; Neurocognition; Cardiovascular health; African Americans; Caucasians; Whites; ALZHEIMERS-DISEASE; PHYSICAL-ACTIVITY; AMERICAN; DEMENTIA; ASSOCIATION; CHOICE; PREVALENCE; STROKE; IMPACT;

D O I：

10.1016/j.jalz.2017.11.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: The aim was to examine associations between midlife cardiovascular health (CVH) and 20-year cognitive decline among blacks and whites. Methods: Midlife CVH metrics (American Heart Association's Life's Simple 7) were calculated and examined in relation to midlife and 20-year change in cognitive function among 13,270 whites and blacks from the Atherosclerosis Risk in Communities Cohort Study. We used linear mixed models to estimate adjusted associations of midlife CVH with midlife cognitive status and change. Results: Higher midlife (Life's Simple 7) scores and individual metrics, particularly blood pressure and glucose, were associated with better midlife cognition and reduced 20-year decline. Midlife CVH 20-year neuroprotection was more pronounced among whites than blacks. Discussion: Better midlife CVH was associated with higher midlife and reduced decline in cognitive function 20 years later. However, the benefits of midlife CVH on cognition were stronger for whites than for blacks. Our findings suggest that improved midlife CVH may promote enduring cognitive health. (C) 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：579 / 589

页数：11

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