Copper-Mediated Direct Aryloxylation of Benzamides Assisted by an N,O-Bidentate Directing Group

被引：104

作者：

Hao, Xin-Qi ^{[1
]}

Chen, Li-Juan ^{[1
]}

Ren, Baozeng ^{[2
]}

Li, Liu-Yan ^{[1
]}

Yang, Xin-Yan ^{[1
]}

Gong, Jun-Fang ^{[1
]}

Niu, Jun-Long ^{[1
]}

Song, Mao-Ping ^{[1
]}

机构：

[1] Zhengzhou Univ, Henan Key Lab Chem Biol & Organ Chem, Coll Chem & Mol Engn, Zhengzhou 450001, Peoples R China

[2] Zhengzhou Univ, Sch Chem Engn & Energy, Zhengzhou 450001, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 04期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; BIDENTATE-CHELATION ASSISTANCE; CROSS-COUPLING REACTIONS; DIARYL ETHERS; AROMATIC AMIDES; DIRECT ARYLATION; ACID DERIVATIVES; ACTIVATION; ARYL; FUNCTIONALIZATION;

D O I：

10.1021/ol500166d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-mediated selective mono- or diaryloxylation of benzamides has been achieved by using 2-aminopyridine 1-oxide as a new and removable N,O-bidentate directing group. The reaction system shows a broad substrate scope and provides a straightforward way for the synthesis of mono- and diaryloxylated benzoic acids.

引用

页码：1104 / 1107

页数：4

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