MUC1 and HER2 might be Associated with Invasive Phenotype of Intraductal Papillary Mucinous Neoplasm

被引：7

作者：

Ohira, Go ^{[1
]}

Kimura, Kenjiro ^{[1
]}

Yamada, Nobuya ^{[1
]}

Amano, Ryosuke ^{[1
]}

Nakata, Bunzo ^{[1
]}

Doi, Yosuke ^{[1
]}

Murata, Akihiro ^{[1
]}

Yashiro, Masakazu ^{[1
]}

Tanaka, Sayaka ^{[2
]}

Ohsawa, Masahiko ^{[2
]}

Wakasa, Kenichi ^{[2
]}

Hirakawa, Kosei ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Surg Oncol, Osaka 5458585, Japan

[2] Osaka City Univ, Grad Sch Med, Dept Diagnost Pathol, Osaka 5458585, Japan

来源：

HEPATO-GASTROENTEROLOGY | 2013年 / 60卷 / 125期

关键词：

Intraductal papillary mucinous neoplasm; MUC1; HER2; CLINICOPATHOLOGICAL FEATURES; DUCTAL ADENOCARCINOMA; SURGICAL RESECTION; PREDICTIVE FACTORS; PANCREAS; TUMORS; EXPRESSION; PROGNOSIS; SURVIVAL; MALIGNANCY;

D O I：

10.5754/hge121268

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: The purpose of this study was to clarify the biomarkers which distinguish invasive intraductal papillary mucinous neoplasms (IPMNs) from non-invasive IPMNs. Methodology: In-tumor specimens from sixty patients with IPMNs (42 non-invasive IPMNs and 18 invasive IPMNs) who underwent surgical resection at our institute, were analyzed for correlation between the immunohistochemical expression levels of MUC1, MUC2, MUC4, MUC5AC, p53, VEGFR2, HER2, and HER3. Results: The 5-year survival rate was 100% in non-invasive IPMNs, while that of invasive IPMNs was only 36.5%. MUC1, MUC4, HER2 and HER3 were significantly associated with invasive IPMNs in univariate analysis. Multivariate analysis revealed that MUC1 and HER2 were significantly associated with invasive IPMNs. The 5-year survival of IPMN patients with either MUC1-positive and/or HER2positive (54.5%) is significantly poorer than that of IPMN patients with MUC1 negative and HER2 negative (100%). Conclusions: MUC1 and HER2 might be closely associated with invasive phenotype of IPMNs.

引用

页码：1067 / 1072

页数：6

共 35 条

[1] Comparative evaluation of the prognostic value of MUC1, MUC2, sialyl-Lewisa and sialyl-Lewisx antigens in colorectal adenocarcinoma [J].

Baldus, SE ;

Mönig, SP ;

Hanisch, FG ;

Zirbes, TK ;

Flucke, U ;

Oelert, S ;

Zilkens, G ;

Madejczik, B ;

Thiele, J ;

Schneider, PM ;

Hölscher, AH ;

Dienes, HP .

HISTOPATHOLOGY, 2002, 40 (05) :440-449

[2] Aberrant p16INK4A and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma [J].

Biankin, AV ;

Biankin, SA ;

Kench, JG ;

Morey, AL ;

Lee, CS ;

Head, DR ;

Eckstein, RP ;

Hugh, TB ;

Henshall, SM ;

Sutherland, RL .

GUT, 2002, 50 (06) :861-868

[3] Cell signaling through membrane mucins [J].

Carraway, KL ;

Ramsauer, VP ;

Haq, B ;

Carraway, CAC .

BIOESSAYS, 2003, 25 (01) :66-71

[4] Histologic, Immunohistochemical, and Molecular Classification of 52 IPMNs of the Pancreas [J].

Chadwick, Barbara ;

Willmore-Payne, Carlynn ;

Tripp, Sheryl ;

Layfield, Lester J. ;

Hirschowitz, Sharon ;

Holden, Joseph .

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2009, 17 (01) :31-39

[5] Study of recurrence after surgical resection of intraductal papillary mucinous neoplasm of the pancreas [J].

Chari, ST ;

Yadav, D ;

Smyrk, TC ;

DiMagno, EP ;

Miller, LJ ;

Raimondo, M ;

Clain, JE ;

Norton, IA ;

Pearson, RK ;

Petersen, BT ;

Wiersema, MJ ;

Farnell, MB ;

Sarr, MG .

GASTROENTEROLOGY, 2002, 123 (05) :1500-1507

[6] Clinicopathological features and treatment of intraductal papillary mucinous tumour of the pancreas [J].

Falconi, M ;

Salvia, R ;

Bassi, C ;

Zamboni, G ;

Talamini, G ;

Pederzoli, P .

BRITISH JOURNAL OF SURGERY, 2001, 88 (03) :376-381

[7] Role of serum carbohydrate antigen 19-9 and carcinoembryonic antigen in distinguishing between benign and invasive intraductal papillary mucinous neoplasm of the pancreas [J].

Fritz, S. ;

Hackert, T. ;

Hinz, U. ;

Hartwig, W. ;

Buechler, M. W. ;

Werner, J. .

BRITISH JOURNAL OF SURGERY, 2011, 98 (01) :104-110

[8] MUC1 core protein as a marker of gallbladder malignancy [J].

Ghosh, M ;

Kamma, H ;

Kawamoto, T ;

Koike, N ;

Miwa, M ;

Kapoor, V ;

Krishnani, N ;

Agrawal, S ;

Ohkohchi, N ;

Todoroki, T .

EJSO, 2005, 31 (08) :891-896

[9] MUC1 (episialin) expression in non-small cell lung cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients [J].

Guddo, F ;

Giatromanolaki, A ;

Koukourakis, MI ;

Reina, C ;

Vignola, AM ;

Chlouverakis, G ;

Hilkens, J ;

Gatter, KC ;

Harris, AL ;

Bonsignore, G .

JOURNAL OF CLINICAL PATHOLOGY, 1998, 51 (09) :667-671

[10] Mucin expression profile is related to biological and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas [J].

Ito, H ;

Endo, T ;

Oka, T ;

Matumoto, T ;

Abe, T ;

Toyota, M ;

Imai, K ;

Satoh, M ;

Maguchi, H ;

Shinohara, T .

PANCREAS, 2005, 30 (04) :E96-E102

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