Actin-Aggregating Cucurbitacins from Physocarpus capitatus

被引：25

作者：

Maloney, Katherine N. ^{[1
]}

Fujita, Masaki ^{[1
]}

Eggert, Ulrike S. ^{[1
,3
]}

Schroeder, Frank C. ^{[1
]}

Field, Christine M. ^{[2
]}

Mitchison, Timothy J. ^{[2
]}

Clardy, Jon ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 11期

关键词：

D O I：

10.1021/np8005259

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of Physocarpus capitatus yielded two new cucurbitacins (3 and 4) along with the known cucurbitacin F (1) and dihydrocucurbitacin F (2). Preliminary mechanism of action studies indicate that the cucurbitacins cause actin aggregates and inhibit cell division.

引用

页码：1927 / 1929

页数：3

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