Treadmill exercise promotes interleukin 15 expression in skeletal muscle and interleukin 15 receptor alpha expression in adipose tissue of high-fat diet rats

被引：55
作者：
Yang, Hongtao [1 ]
Chang, Jinrui [2 ]
Chen, Wenjia [3 ]
Zhao, Lei [2 ]
Qu, Bo [1 ]
Tang, Chaoshu [2 ]
Qi, Yongfen [2 ]
Zhang, Jing [1 ]
机构：
[1] Beijing Normal Univ, Sch PE & Sports Sci, Beijing 100875, Peoples R China
[2] Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
[3] Harbin Med Univ, Affiliated Hosp 1, Dept Cardiol, Harbin 150001, Peoples R China
来源：
ENDOCRINE | 2013年 / 43卷 / 03期
基金：
中国国家自然科学基金; 北京市自然科学基金;
关键词：
Interleukin-15; Treadmill running; Obesity; Skeletal muscle; PRIMARY PIG ADIPOCYTES; IL-2; RECEPTOR; BETA-CHAIN; OBESITY; MYOKINES; CELLS; ASSOCIATION; RESISTANCE; COMPLEXES; PROTEIN;
D O I：
10.1007/s12020-012-9809-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Interleukin 15 (IL-15) has recently been proposed as a myokine involved in regulating lipid metabolism. We investigated the effect of exercise training on IL-15 content in skeletal muscle and expression of IL-15 receptor (IL-15R) in adipose tissue of obese rats. After 12 weeks of a high-fat diet, obese rats underwent treadmill running at 26 m/min (60 min each, 5 days/week for 8 weeks). High-fat diet induced obesity, with increased body weight, body fat, and lipid profile. The level of IL-15 immunoreactivity (IL-15-ir) in plasma and gastrocnemius muscle was lower in obese than control rats, and the mRNA level of IL-15 in gastrocnemius muscle was markedly decreased. The mRNA and protein levels of IL-15R in adipose tissue were markedly lower in obese rats. Compared with sedentary obese rats, treadmill running showed decreased body weight and elevated mRNA expression of IL-15 in muscle and elevated IL-15-ir level in plasma and muscle. The mRNA and protein level of IL-15R were increased in adipose tissue in treadmill running obese rats. Our results showed that exercise training improve obesity and reversed the downregulation of the IL-15 in muscle and IL-15R in adipose tissue induced by high-fat diet.
引用
收藏
页码：579 / 585
页数：7
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