Neuroprotective diterpenes from the fruiting body of Antrodia camphorata

被引：85

作者：

Chen, CC

Shiao, YJ

Lin, RD

Shao, YY

Lai, MN

Lin, CC

Ng, LT

Kuo, YH ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[2] Natl Res Inst Chinese Med, Taipei 112, Taiwan

[3] Shih Chien Univ, Dept Food Sci Nutr & Nutraceut Biotechnol, Taipei 104, Taiwan

[4] Kang Jian Biotech Corp Ltd, Nantou 542, Taiwan

[5] Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, Taiwan

[6] Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, Taiwan

[7] Ta Jen Univ, Dept Biotechnol, Pingtung 907, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 04期

关键词：

D O I：

10.1021/np0581263

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new compounds, 19-hydroxylabda-8(17)-en-16,15-olide ( 1), 3 beta,19- dihydroxylabda-8(17), 11E- dien-16,15-olide ( 2), and 13-epi-3 beta,19-dihydroxylabda- 8( 17), 11E-dien-16,15-olide ( 3), together with four known compounds, 19-hydroxylabda- 8( 17), 13-dien-16,15-olide ( 4), 14-deoxy-11,12-didehydroandrographolide ( 5), 14-deoxyandrographolide, and pinusolidic acid, were isolated from the fruiting bodies of Antrodia camphorata. The structures of compounds 1-3 were elucidated by the analysis of their spectroscopic data. The in vitro neuroprotective activity of all compounds was evaluated, and compounds 1-5 protected neurons from A beta damage by 39.2, 35.0, 36.7, 30.6, and 27.0%, respectively, at concentrations between 5 and 20 mu M.

引用

页码：689 / 691

页数：3

共 23 条

[1] New steroid acids from Antrodia cinnamomea, a fungal parasite of Cinnamomum micranthum [J].