Palladium-Catalyzed Decarboxylative γ-Olefination of 2,5-Cyclohexadiene-1-carboxylic Acid Derivatives with Vinyl Halides

被引：11

作者：

Chang, Chi-Hao ^{[1
]}

Chou, Chih-Ming ^{[1
]}

机构：

[1] Natl Univ Kaohsiung, Dept Appl Chem, 700 Kaohsiung Univ Rd, Kaohsiung 81148, Taiwan

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 07期

关键词：

C-H OLEFINATION; ALPHA-OXOCARBOXYLIC ACIDS; CROSS-COUPLING REACTIONS; CARBOXYLIC-ACIDS; CONJUGATED POLYMERS; CINNAMIC-ACIDS; HECK REACTION; ACTIVATION; ARYLATION; FUNCTIONALIZATION;

D O I：

10.1021/acs.orglett.8b00486

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This study explores a Pd-catalyzed decarboxylative Heck-type Csp(3)-Csp(2) coupling reaction of 2,5-cyclohexadiene-1-carboxylic acid derivatives with vinyl halides to provide gamma-olefination products. The olefinated 1,3-cyclohexadienes can be further oxidized to produce meta-alkylated stilbene derivatives. Additionally, the conjugated diene products can also undergo a Diels-Alder reaction to produce a bicyclo[2.2.2]octadiene framework.

引用

页码：1949 / 1952

页数：4

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