Tetrabenazine

被引：47

作者：

Hayden, Michael R. ^{[1
]}

Leavitt, Blair R. ^{[1
]}

Yasothan, Uma ^{[2
]}

Kirkpatrick, Peter

机构：

[1] Univ British Columbia, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada

[2] IMS Hlth, London NW1 6JB, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2009年 / 8卷 / 01期

关键词：

HUNTINGTONS-DISEASE; CHOREA;

D O I：

10.1038/nrd2784

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In August 2008, tetrabenazine (Xenazine; Ovation Pharmaceuticals/ Biovail) was approved by the US FDA for the treatment of chorea associated with Huntington's disease. This makes it the first treatment to be approved in the US for a symptom of this neurodegenerative disorder.

引用

页码：17 / 18

页数：2

共 14 条

[1] EFFECT OF TETRABENAZINE ON EXTRAPYRAMIDAL MOVEMENT DISORDERS [J].

DALBY, MA .

BRITISH MEDICAL JOURNAL, 1969, 2 (5654) :422-&

[2]

*FDA, 2008, FDA LAB INF

[3]

Frank SA, 2004, NEUROLOGY, V62, pA204

[4]

GIBBS L, 2008, NEWCREST BIOVAIL RES

[5] Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin [J].

Graham, Rona K. ;

Deng, Yu ;

Slow, Elizabeth J. ;

Haigh, Brendan ;

Bissada, Nagat ;

Lu, Ge ;

Pearson, Jacqueline ;

Shehadeh, Jacqueline ;

Bertram, Lisa ;

Murphy, Zoe ;

Warby, Simon C. ;

Doty, Crystal N. ;

Roy, Sophie ;

Wellinpton, Cheryl L. ;

Leavitt, Blair R. ;

Raymond, Lynn A. ;

Nicholson, Donald W. ;

Hayden, Michael R. .

CELL, 2006, 125 (06) :1179-1191

[6]

Grimbergen Yvette A M, 2003, Curr Opin Investig Drugs, V4, P51

[7]

JANKOVIC J, 1983, ADV NEUROL, V37, P227

[8] Huntingtin and the molecular pathogenesis of Huntington's disease - Fourth in molecular medicine review series [J].

Landles, C ;

Bates, GP .

EMBO REPORTS, 2004, 5 (10) :958-963

[9]

LEAVITT BR, 2000, KELLEYS TXB INTERNAL

[10] Tetrabenazine as antichorea therapy in Huntington disease - A randomized controlled trial [J].

Marshall, FJ ;

Walker, F ;

Frank, S ;

Oakes, D ;

Plumb, S ;

Factor, SA ;

Fahn, S ;

Hunt, VP ;

Jankovic, J ;

Shinaman, A ;

Shoulson, I ;

Goldstein, J ;

Corey-Bloom, J ;

Belden, J ;

Wojcieszek, J ;

Nickerson, C ;

Higgins, D ;

McCall, M ;

Sanchez-Ramos, J ;

Stepanov, N ;

Kostyk, S ;

Harrison, J ;

Testa, C ;

Shannon, B ;

Feigin, A ;

Radtke, D ;

Nance, M ;

Stanton, P ;

Ashizawa, T ;

Hunter, C ;

Ondo, W ;

Rose, K ;

Geschwind, M ;

Jaglin, J ;

Shannon, K ;

Matthews, M ;

Colcher, A ;

Riendl, P ;

Blindauer, K ;

Dustin, K ;

Anderson, K ;

Fowler, S ;

Mehta, D ;

Hanna, P ;

Lindsay, P ;

Eberly, S ;

Zhao, HW ;

MacDonald, M ;

Young, A .

NEUROLOGY, 2006, 66 (03) :366-372

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