Tetrabenazine

被引:46
作者
Hayden, Michael R. [1 ]
Leavitt, Blair R. [1 ]
Yasothan, Uma [2 ]
Kirkpatrick, Peter
机构
[1] Univ British Columbia, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
[2] IMS Hlth, London NW1 6JB, England
关键词
HUNTINGTONS-DISEASE; CHOREA;
D O I
10.1038/nrd2784
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
In August 2008, tetrabenazine (Xenazine; Ovation Pharmaceuticals/ Biovail) was approved by the US FDA for the treatment of chorea associated with Huntington's disease. This makes it the first treatment to be approved in the US for a symptom of this neurodegenerative disorder.
引用
收藏
页码:17 / 18
页数:2
相关论文
共 14 条
  • [1] EFFECT OF TETRABENAZINE ON EXTRAPYRAMIDAL MOVEMENT DISORDERS
    DALBY, MA
    [J]. BRITISH MEDICAL JOURNAL, 1969, 2 (5654) : 422 - &
  • [2] *FDA, 2008, FDA LAB INF
  • [3] Frank SA, 2004, NEUROLOGY, V62, pA204
  • [4] GIBBS L, 2008, NEWCREST BIOVAIL RES
  • [5] Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
    Graham, Rona K.
    Deng, Yu
    Slow, Elizabeth J.
    Haigh, Brendan
    Bissada, Nagat
    Lu, Ge
    Pearson, Jacqueline
    Shehadeh, Jacqueline
    Bertram, Lisa
    Murphy, Zoe
    Warby, Simon C.
    Doty, Crystal N.
    Roy, Sophie
    Wellinpton, Cheryl L.
    Leavitt, Blair R.
    Raymond, Lynn A.
    Nicholson, Donald W.
    Hayden, Michael R.
    [J]. CELL, 2006, 125 (06) : 1179 - 1191
  • [6] Grimbergen Yvette A M, 2003, Curr Opin Investig Drugs, V4, P51
  • [7] JANKOVIC J, 1983, ADV NEUROL, V37, P227
  • [8] Huntingtin and the molecular pathogenesis of Huntington's disease - Fourth in molecular medicine review series
    Landles, C
    Bates, GP
    [J]. EMBO REPORTS, 2004, 5 (10) : 958 - 963
  • [9] LEAVITT BR, 2000, KELLEYS TXB INTERNAL
  • [10] Tetrabenazine as antichorea therapy in Huntington disease - A randomized controlled trial
    Marshall, FJ
    Walker, F
    Frank, S
    Oakes, D
    Plumb, S
    Factor, SA
    Fahn, S
    Hunt, VP
    Jankovic, J
    Shinaman, A
    Shoulson, I
    Goldstein, J
    Corey-Bloom, J
    Belden, J
    Wojcieszek, J
    Nickerson, C
    Higgins, D
    McCall, M
    Sanchez-Ramos, J
    Stepanov, N
    Kostyk, S
    Harrison, J
    Testa, C
    Shannon, B
    Feigin, A
    Radtke, D
    Nance, M
    Stanton, P
    Ashizawa, T
    Hunter, C
    Ondo, W
    Rose, K
    Geschwind, M
    Jaglin, J
    Shannon, K
    Matthews, M
    Colcher, A
    Riendl, P
    Blindauer, K
    Dustin, K
    Anderson, K
    Fowler, S
    Mehta, D
    Hanna, P
    Lindsay, P
    Eberly, S
    Zhao, HW
    MacDonald, M
    Young, A
    [J]. NEUROLOGY, 2006, 66 (03) : 366 - 372