Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland: Findings from an International Workshop

被引：10

作者：

Nikolaidis, Christos ^{[1
]}

Ming, Chang ^{[1
]}

Pedrazzani, Carla ^{[1
,6
]}

van der Horst, Tina ^{[1
]}

Kaiser-Grolimund, Andrea ^{[1
]}

Ademi, Zanfina ^{[2
,3
]}

Buehrer-Landolt, Rosmarie ^{[4
]}

Buerki, Nicole ^{[5
]}

Caiata-Zufferey, Maria ^{[6
]}

Champion, Victoria ^{[7
]}

Chappuis, Pierre O. ^{[8
,9
]}

Kohler, Carmen ^{[1
,5
]}

Erlanger, Tobias E. ^{[10
]}

Graffeok, Rossella ^{[11
]}

Hampel, Heather ^{[12
]}

Heinimann, Karl ^{[13
,14
]}

Heinzelmann-Schwarz, Viola ^{[5
]}

Kurzeder, Christian ^{[5
]}

Monnerat, Christian ^{[15
]}

Northouse, Laurel L. ^{[16
]}

Pagani, Olivia ^{[11
]}

Probst-Hensch, Nicole ^{[17
]}

Rabaglio, Manuela ^{[4
]}

Schoenau, Eveline ^{[5
]}

Sijbrands, Eric J. G. ^{[18
]}

Taborelli, Monika ^{[11
]}

Urech, Corinne ^{[5
]}

Viassolo, Valeria ^{[9
]}

Wieser, Simon ^{[19
]}

Katapodi, Maria C. ^{[1
,16
]}

机构：

[1] Univ Basel, Inst Nursing Sci, Dept Publ Hlth, Basel, Switzerland

[2] Univ Basel, European Ctr Pharmaceut Med, Basel, Switzerland

[3] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia

[4] Inselspital Bern, Univ Clin Med Oncol, Bern, Switzerland

[5] Univ Basel, Univ Hosp Basel, Womens Clin & Gynecol Oncol, Basel, Switzerland

[6] Univ Appl Sci & Arts Southern Switzerland, Manno, Switzerland

[7] Indiana Univ, Sch Nursing, Indianapolis, IN 46204 USA

[8] Univ Geneva, Geneva Univ Hosp, Div Genet Med, Geneva, Switzerland

[9] Geneva Univ Hosp, Div Oncol, Unit Oncogenet & Canc Prevent, Geneva, Switzerland

[10] Univ Hosp Basel, Dept Clin Res, Clin Trial Unit, Basel, Switzerland

[11] Inst Oncol & Breast, Unit Southern Switzerland, Bellinzona, Switzerland

[12] Ohio State Univ, Dept Internal Med, Div Human Genet, Comprehens Canc Ctr, Columbus, OH 43210 USA

[13] Univ Hosp Basel, Inst Med Genet & Pathol, Basel, Switzerland

[14] Univ Basel, Dept Biomed, Res Grp Human Genom, Basel, Switzerland

[15] Hosp Jura, Oncol Serv, Delemont, Switzerland

[16] Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA

[17] Univ Basel, Swiss Trop & Publ Hlth Inst, Basel, Switzerland

[18] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

[19] Zurich Univ Appl Sci, Winterthur Inst Hlth Econ, Winterthur, Switzerland

来源：

PUBLIC HEALTH GENOMICS | 2018年 / 21卷 / 3-4期

基金：

瑞士国家科学基金会;

关键词：

Cascade genetic screening; Hereditary breast and ovarian cancer; Lynch syndrome; Implementation science; Public health genetics; FAMILIAL HYPERCHOLESTEROLEMIA; COLORECTAL-CANCER; ECONOMIC-EVALUATION; COST-EFFECTIVENESS; GENE-MUTATIONS; RISK; GUIDELINES; MANAGEMENT; METAANALYSIS; PERSPECTIVE;

D O I：

10.1159/000496495

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: An international workshop on cancer predisposition cascade genetic screening for hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) took place in Switzerland, with leading researchers and clinicians in cascade screening and hereditary cancer from different disciplines. The purpose of the workshop was to enhance the implementation of cascade genetic screening in Switzerland. Participants discussed the challenges and opportunities associated with cascade screening for HBOC and LS in Switzerland (CASCADE study); family implications and the need for family-based interventions; the need to evaluate the cost-effectiveness of cascade genetic screening; and interprofessional collaboration needed to lead this initiative. Methods: The workshop aims were achieved through exchange of data and experiences from successful cascade screening programs in the Netherlands, Australia, and the state of Ohio, USA; Swiss-based studies and scientific experience that support cancer cascade screening in Switzerland; programs of research in psychosocial oncology and family-based studies; data from previous cost-effectiveness analyses of cascade genetic screening in the Netherlands and in Australia; and organizational experience from a large interprofessional collaborative. Scientific presentations were recorded and discussions were synthesized to present the workshop findings. Results: The key elements of successful implementation of cascade genetic screening are a supportive network of stakeholders and connection to complementary initiatives; sample size and recruitment of relatives; centralized organization of services; data-based cost-effectiveness analyses; transparent organization of the initiative; and continuous funding. Conclusions: This paper describes the processes and key findings of an international workshop on cancer predisposition cascade screening, which will guide the CASCADE study in Switzerland. (C) 2019 S. Karger AG, Basel

引用

页码：121 / 132

页数：12

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