Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species

被引：609

作者：

Ma, Ping'an ^{[1
]}

Xiao, Haihua ^{[2
]}

Yu, Chang ^{[1
,3
]}

Liu, Jianhua ^{[4
,5
]}

Cheng, Ziyong ^{[1
]}

Song, Haiqin ^{[1
]}

Zhang, Xinyang ^{[1
]}

Li, Chunxia ^{[1
]}

Wang, Jinqiang ^{[6
,7
]}

Gu, Zhen ^{[6
,7
]}

Lin, Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] Jilin Univ, Hosp 2, Dept Radiol, Changchun 130041, Peoples R China

[5] Jilin Univ, Coll Chem, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Peoples R China

[6] Univ N Carolina, Joint Dept Biomed Engn, Chapel Hill, NC USA

[7] North Carolina State Univ, Raleigh, NC 27695 USA

来源：

NANO LETTERS | 2017年 / 17卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Drug delivery; cisplatin; iron oxide; Fenton's reaction; reactive oxygen species; MOTEXAFIN GADOLINIUM; DELIVERY; DRUG; PRODRUG; MECHANISMS; RESISTANCE; NANOPARTICLES; INFLAMMATION; ARTEMISININS; OTOTOXICITY;

D O I：

10.1021/acs.nanolett.6b04269

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reactive oxygen species (ROS) plays a key role in therapeutic effects as well as side effects of platinum drugs. Cisplatin mediates activation of nicotinamide adenine dinudeotide phosphate (NADPH) oxidase (NOX), which triggers oxygen (O-2) to superoxide radical (O-2(center dot-)) and its downstream H2O2. Through the Fenton's reaction, H2O2 could be catalyzed by Fe2+/Fe3+ to the toxic hydroxyl radicals ((OH)-O-center dot), which cause oxidative damages to lipids, proteins, and DNA. By taking the full advantage of Fenton's chemistry, we herein demonstrated tumor site-specific conversion of ROS generation induced by released cisplatin and Fe2+/Fe3+ from iron-oxide nanocarriers with cisplatin(IV) prodrugs for enhanced anticancer activity but minimized systemic toxicity.

引用

页码：928 / 937

页数：10

共 57 条

[51] Reactive oxygen species-related activities of nano-iron metal and nano-iron oxides [J].

Wu, Haohao ;

Yin, Jun-Jie ;

Wamer, Wayne G. ;

Zeng, Mingyong ;

Lo, Y. Martin .

JOURNAL OF FOOD AND DRUG ANALYSIS, 2014, 22 (01) :86-94

[52] A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance [J].

Xiao, Haihua ;

Song, Haiqin ;

Yang, Qiang ;

Cai, Haidong ;

Qi, Ruogu ;

Yan, Lesan ;

Liu, Shi ;

Zheng, Yonghui ;

Huang, Yubin ;

Liu, Tongjun ;

Jing, Xiabin .

BIOMATERIALS, 2012, 33 (27) :6507-6519

[53] Biodegradable polymer - cisplatin(IV) conjugate as a pro-drug of cisplatin(II) [J].

Xiao, Haihua ;

Qi, Ruogu ;

Liu, Shi ;

Hu, Xiuli ;

Duan, Taicheng ;

Zheng, Yonghui ;

Huang, Yubin ;

Jing, Xiabin .

BIOMATERIALS, 2011, 32 (30) :7732-7739

[54] Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug [J].

Xu, Xiaoyang ;

Xie, Kun ;

Zhang, Xue-Qing ;

Pridgen, Eric M. ;

Park, Ga Young ;

Cui, Danica S. ;

Shi, Jinjun ;

Wu, Jun ;

Kantoff, Philip W. ;

Lippard, Stephen J. ;

Langer, Robert ;

Walker, Graham C. ;

Farokhzad, Omid C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (46) :18638-18643

[55] Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction [J].

Zhang, Chen ;

Bu, Wenbo ;

Ni, Dalong ;

Zhang, Shenjian ;

Li, Qing ;

Yao, Zhenwei ;

Zhang, Jiawen ;

Yao, Heliang ;

Wang, Zheng ;

Shi, Jianlin .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (06) :2101-2106

[56] Tuning with pH: The selectivity of a new rhodamine B derivative chemosensor for Fe3+ and Cu2+ [J].

Zhang, Ling-Fei ;

Zhao, Jiang-Lin ;

Zeng, Xi ;

Mu, Lan ;

Jiang, Xue-Kai ;

Deng, Min ;

Zhang, Jian-Xin ;

Wei, Gang .

SENSORS AND ACTUATORS B-CHEMICAL, 2011, 160 (01) :662-669

[57] The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental mice [J].

Zhang, Wei-Jian ;

Wei, Hao ;

Frei, Balz .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2010, 235 (05) :633-641

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