Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species

被引：609

作者：

Ma, Ping'an ^{[1
]}

Xiao, Haihua ^{[2
]}

Yu, Chang ^{[1
,3
]}

Liu, Jianhua ^{[4
,5
]}

Cheng, Ziyong ^{[1
]}

Song, Haiqin ^{[1
]}

Zhang, Xinyang ^{[1
]}

Li, Chunxia ^{[1
]}

Wang, Jinqiang ^{[6
,7
]}

Gu, Zhen ^{[6
,7
]}

Lin, Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] Jilin Univ, Hosp 2, Dept Radiol, Changchun 130041, Peoples R China

[5] Jilin Univ, Coll Chem, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Peoples R China

[6] Univ N Carolina, Joint Dept Biomed Engn, Chapel Hill, NC USA

[7] North Carolina State Univ, Raleigh, NC 27695 USA

来源：

NANO LETTERS | 2017年 / 17卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Drug delivery; cisplatin; iron oxide; Fenton's reaction; reactive oxygen species; MOTEXAFIN GADOLINIUM; DELIVERY; DRUG; PRODRUG; MECHANISMS; RESISTANCE; NANOPARTICLES; INFLAMMATION; ARTEMISININS; OTOTOXICITY;

D O I：

10.1021/acs.nanolett.6b04269

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reactive oxygen species (ROS) plays a key role in therapeutic effects as well as side effects of platinum drugs. Cisplatin mediates activation of nicotinamide adenine dinudeotide phosphate (NADPH) oxidase (NOX), which triggers oxygen (O-2) to superoxide radical (O-2(center dot-)) and its downstream H2O2. Through the Fenton's reaction, H2O2 could be catalyzed by Fe2+/Fe3+ to the toxic hydroxyl radicals ((OH)-O-center dot), which cause oxidative damages to lipids, proteins, and DNA. By taking the full advantage of Fenton's chemistry, we herein demonstrated tumor site-specific conversion of ROS generation induced by released cisplatin and Fe2+/Fe3+ from iron-oxide nanocarriers with cisplatin(IV) prodrugs for enhanced anticancer activity but minimized systemic toxicity.

引用

页码：928 / 937

页数：10

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