Applications of ring closing metathesis. Total synthesis of (±)-pseudotabersonine

被引：14

作者：

Cheng, Bo ^{[1
]}

Sunderhaus, James D. ^{[1
]}

Martin, Stephen F. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Chem, Austin, TX 78712 USA

来源：

TETRAHEDRON | 2015年 / 71卷 / 39期

基金：

美国国家卫生研究院;

关键词：

Double ring-closing metathesis; Multicomponent assembly process; Alkaloid; Total synthesis; MULTICOMPONENT ASSEMBLY PROCESSES; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; HIGHLY EFFICIENT; FACILE SYNTHESES; MANZAMINE-A; ALKALOIDS; DIVERSE; STRATEGY; CONSTRUCTION;

D O I：

10.1016/j.tet.2015.04.082

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel approach to the Aspidosperma family of alkaloids was developed and applied to a concise total synthesis of (+/-)-pseudotabersonine that was accomplished in 11 steps. Key transformations include a stepwise variant of a Mannich-like multicomponent assembly process, a double ring-closing metathesis sequence, and a one-pot deprotection/cyclization reaction. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：7323 / 7331

页数：9