Isoquinoline derivatives as potential acetylcholinesterase inhibitors

被引：40

作者：

Markmee, S

Ruchirawat, S

Prachyawarakorn, V

Ingkaninan, K

Khorana, N ^{[1
]}

机构：

[1] Naresuan Univ, Fac Pharmaceut Sci, Dept Pharmaceut Chem & Pharmacognosy, Phitsanulok 65000, Thailand

[2] Chulabhorn Res Inst, Bangkok 10210, Thailand

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 08期

关键词：

isoquinoline; acetylcholinesterase inhibitors; Alzheimer's disease;

D O I：

10.1016/j.bmcl.2006.01.067

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several bisbenzylisoquinoline alkaloid derivatives showed the inhibitory activity at acetylcholinesterase enzyme (AChE) in micromolar range. It is possible that monomeric moiety of bisbenzylisoquinoline alkaloid might be required for acetylcholinesterase enzyme inhibition. AChE inhibitory activity of related monomeric 1-benzylisoquinolines was examined by using Ellman colorimetric assay with galanthamine as a reference standard. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2170 / 2172

页数：3

共 13 条

[1] Is there a rationale for the use of acetylcholinesterase inhibitors in the therapy of Alzheimer's disease? [J].