Bilateral basal ganglia lesions as initial manifestation of CNS invasion in adult T-cell leukemia

被引：0

作者：

Matsuo, Yoshimasa ^{[1
]}

Yamashita, Satoshi ^{[1
]}

Honda, Shoji ^{[1
]}

Nakajima, Makoto ^{[2
]}

Ueda, Akihiko ^{[1
]}

Hirahara, Tomoo ^{[1
]}

Yamashita, Taro ^{[1
]}

Maeda, Yasushi ^{[1
]}

Hirano, Teruyuki ^{[1
]}

Ando, Yukio ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Med Sci, Dept Neurol, Kumamoto 8608556, Japan

[2] Saiseikai Kumamoto Hosp, Dept Neurol, Stroke Ctr, Kumamoto 8614193, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2013年 / 327卷 / 1-2期

关键词：

Adult T-cell leukemia; Human T-cell leukemia virus type I; Central nervous system; Bilateral basal ganglia; Direct infiltration; Positron emission tomography; LEUKEMIA/LYMPHOMA;

D O I：

10.1016/j.jns.2013.01.035

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe the case of a 67-year-old man who exhibited unsteadiness in walking, topographical disorientation, and urinary incontinence. Neurological examination revealed somnolence and mild weakness in the lower limbs with slight rigidity in the upper limbs. Cerebrospinal fluid examination showed pleocytosis with "flower cells" and an extremely high level of soluble interleukin-2 receptor. T2-weighted brain imaging revealed symmetrical high-intensity lesions in the bilateral caudate putamen. Positron emission tomography demonstrated intense uptake of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose in the same region. He was diagnosed with central nervous system invasion by adult T-cell leukemia (An) and received chemotherapy. Interestingly, chemotherapy ameliorated the lesions and terminally caused the gray matter itself to atrophy in the bilateral caudate nuclei, which may be evidence for the direct Infiltration of ATL tumors. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：63 / 64

页数：2

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