Palladium-catalyzed highly regio- and stereoselective carbon-carbon bond formation reaction of γ-substituted vinylaziridines with a silylated masked acyl cyanide reagent

被引：11

作者：

Kawamura, Tomoyuki ^{[1
]}

Matsu, Nanae ^{[2
]}

Yamauchi, Daisuke ^{[1
]}

Tanabe, Yoo ^{[2
]}

Nemoto, Hisao ^{[1
]}

机构：

[1] Univ Tokushima, Grad Sch, Div Heath Biosci, Dept Pharmaceut Chem, Tokushima 7708505, Japan

[2] Kwansei Gakuin Univ, Sch Sci & Technol, Dept Chem, Sanda 6691337, Japan

来源：

TETRAHEDRON | 2013年 / 69卷 / 26期

关键词：

Palladium; Aziridine; pi-Allyl complex; Masked acyl cyanide; RING-OPENING REACTIONS; BETA-SUBSTITUENTS; ACID; PRONUCLEOPHILES; ALLYLATION; COMPLEXES; BEARING; ALPHA;

D O I：

10.1016/j.tet.2013.04.129

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly regio- and stereoselective carbon-carbon bond formation reaction of vinylaziridines using a masked acyl cyanide reagent possessing a tert-butyldimethylsilyl group occurred in the presence of a catalytic amount of palladium complex in excellent yield. It is considered that these excellent selectivities are the result of three simultaneous conditions, strained leaving group, small nucleophile, and ligand with small cone-angle. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：5331 / 5341

页数：11

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