Molecular aspects of embryonic hemoglobin function

被引：54

作者：

Brittain, Thomas ^{[1
]}

机构：

[1] Univ Auckland, Sch Biol Sci, Auckland 1, New Zealand

来源：

MOLECULAR ASPECTS OF MEDICINE | 2002年 / 23卷 / 04期

关键词：

Hemoglobin; Embryonic; Development; Function; Structure;

D O I：

10.1016/S0098-2997(02)00004-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to provide the appropriate level of oxygen transport to respiring tissues, we need to produce a molecular oxygen transporting system to supplement oxygen diffusion and solubility. This supplementation is provided by hemoglobin. The role of hemoglobin in providing oxygen transport from lung to tissues in the adult is well-documented and functional characteristics of the fetal hemoglobin, which provide placental oxygen exchange, are also well understood. However the characteristics of the three embryonic hemoglobins, which provide oxygen transport during the first three months of gestation, are not well recognized. This review seeks to describe the state of our understanding of the temporal control of the expression of these proteins and the oxygen binding characteristics of the individual protein molecules. The modulation of the oxygen binding properties of these proteins, by the various allosteric effectors, is described and the structural origins of these characteristics are probed. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：293 / 342

页数：50

共 279 条

[21] THE 1.8-ANGSTROM STRUCTURE OF CARBONMONOXY-BETA(4) HEMOGLOBIN - ANALYSIS OF A HOMOTETRAMER WITH THE R-QUATERNARY STRUCTURE OF LIGANDED ALPHA(2)BETA(2) HEMOGLOBIN [J].

BORGSTAHL, GEO ;

ROGERS, PH ;

ARNONE, A .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 236 (03) :817-830

[22] FETAL HEMOGLOBIN RESTRICTION TO A FEW ERYTHROCYTES (F CELLS) IN NORMAL HUMAN ADULTS [J].

BOYER, SH ;

BELDING, TK ;

MARGOLET, L ;

NOYES, AN .

SCIENCE, 1975, 188 (4186) :361-363

[23] A two-state analysis of co-operative oxygen binding in the three human embryonic haemoglobins [J].

Brittain, T ;

Hofmann, OM ;

Watmough, NJ ;

Greenwood, C ;

Weber, RE .

BIOCHEMICAL JOURNAL, 1997, 326 :299-303

[24] Electron transfer between cytochrome b5 and some oxidised haemoglobins:: the role of ionic strength [J].

Brittain, T ;

Kidd, RD ;

Baker, EN .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2002, 88 (3-4) :328-334

[25] STOPPED-FLOW KINETICS OF OXYGEN-UPTAKE AND RELEASE BY EMBRYONIC RED BLOOD-CELLS [J].

BRITTAIN, T ;

SIMPSON, R .

BIOCHEMICAL JOURNAL, 1989, 261 (03) :1009-1013

[26] Expression of α- and β-globin genes occurs within different nuclear domains in haemopoietic cells [J].

Brown, KE ;

Amoils, S ;

Horn, JM ;

Buckle, VJ ;

Higgs, DR ;

Merkenschlager, M ;

Fisher, AG .

NATURE CELL BIOLOGY, 2001, 3 (06) :602-606

[27] Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation [J].

Brownell, JE ;

Zhou, JX ;

Ranalli, T ;

Kobayashi, R ;

Edmondson, DG ;

Roth, SY ;

Allis, CD .

CELL, 1996, 84 (06) :843-851

[28] ANION BOHR EFFECT OF HUMAN-HEMOGLOBIN [J].

BUCCI, E ;

FRONTICELLI, C .

BIOCHEMISTRY, 1985, 24 (02) :371-376

[29] Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4 [J].

Bungert, J ;

Dave, U ;

Lim, KC ;

Lieuw, KH ;

Shavit, JA ;

Liu, QH ;

Engel, JD .

GENES & DEVELOPMENT, 1995, 9 (24) :3083-3096

[30] IMMORTALIZATION OF MULTIPOTENT GROWTH-FACTOR DEPENDENT HEMATOPOIETIC PROGENITORS FROM MICE TRANSGENIC FOR GATA-1 DRIVEN SV40 TSA58 GENE [J].

CAIRNS, LA ;

CROTTA, S ;

MINUZZO, M ;

MORONI, E ;

GRANUCCI, F ;

NICOLIS, S ;

SCHIRO, R ;

POZZI, L ;

GIGLIONI, B ;

RICCIARDICASTAGNOLI, P ;

OTTOLENGHI, S .

EMBO JOURNAL, 1994, 13 (19) :4577-4586

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