Evaluation of commercial soft contact lenses for ocular drug delivery: A review

被引：47

作者：

Fan, Xin ^{[1
]}

Torres-Luna, Cesar ^{[2
]}

Azadi, Marjan ^{[1
]}

Domszy, Roman ^{[3
]}

Hu, Naiping ^{[3
]}

Yang, Arthur ^{[3
]}

David, Allan E. ^{[1
]}

机构：

[1] Auburn Univ, Dept Chem Engn, Auburn, AL 36849 USA

[2] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA

[3] Lynthera Corp, 1200 Corp Blvd,STE 10C, Lancaster, PA USA

来源：

ACTA BIOMATERIALIA | 2020年 / 115卷

关键词：

Ocular drug delivery; Contact lenses; Biomaterials; Controlled release; IN-VITRO UPTAKE; SILICONE-HYDROGEL; VITAMIN-E; POSTERIOR SEGMENT; EXTENDED-RELEASE; INTRAVITREAL INJECTION; MACULAR DEGENERATION; THERAPEUTIC-USES; EYE; WEAR;

D O I：

10.1016/j.actbio.2020.08.025

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Soft contact lenses have generated growing interest in ocular drug delivery due to their potential to enhance drug bioavailability in ocular tissues. Commercially available soft contact lenses offer several advantages for ocular drug delivery as they are manufactured on a large scale, which guarantees the availability of a consistent and reproducible product, and their favorable safety profile is well-established through broad clinical use. Here we review the rationale for using commercially available soft contact lenses for ocular drug delivery; summarize the evolution of the materials used in contact lens fabrication; and explore various methods used to improve the drug release characteristics and its tissue penetration. While significant progress has been made, several issues still require further attention for the commercial launch of a viable drug-eluting contact lens product, including control of initial burst release, shelf-life stability, and drug loss during processing or storage. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：60 / 74

页数：15

共 163 条

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