Comparative genomics of the neglected human malaria parasite Plasmodium vivax

被引：624

作者：

Carlton, Jane M. ^{[1
,2
]}

Adams, John H. ^{[3
]}

Silva, Joana C. ^{[4
,5
]}

Bidwell, Shelby L. ^{[1
]}

Lorenzi, Hernan ^{[1
]}

Caler, Elisabet ^{[1
]}

Crabtree, Jonathan ^{[1
,5
]}

Angiuoli, Samuel V. ^{[5
,8
]}

Merino, Emilio F. ^{[2
]}

Amedeo, Paolo ^{[1
]}

Cheng, Qin ^{[9
]}

Coulson, Richard M. R. ^{[10
]}

Crabb, Brendan S. ^{[11
,12
]}

del Portillo, Hernando A. ^{[13
,14
]}

Essien, Kobby ^{[15
,16
,17
]}

Feldblyum, Tamara V. ^{[5
]}

Fernandez-Becerra, Carmen ^{[13
]}

Gilson, Paul R. ^{[11
]}

Gueye, Amy H. ^{[18
]}

Guo, Xiang ^{[1
]}

Kang'a, Simon ^{[2
]}

Kooij, Taco W. A. ^{[19
]}

Korsinczky, Michael ^{[9
,20
]}

Meyer, Esmeralda V. -S. ^{[21
,22
]}

Nene, Vish ^{[4
,5
]}

Paulsen, Ian ^{[1
,23
]}

White, Owen ^{[5
,6
]}

Ralph, Stuart A. ^{[24
]}

Ren, Qinghu ^{[1
]}

Sargeant, Tobias J. ^{[11
,25
]}

Salzberg, Steven L. ^{[8
]}

Stoeckert, Christian J. ^{[15
,16
]}

Sullivan, Steven A. ^{[2
]}

Yamamoto, Marcio M. ^{[26
]}

Hoffman, Stephen L. ^{[27
]}

Wortman, Jennifer R. ^{[5
,7
]}

Gardner, Malcolm J. ^{[1
]}

Galinski, Mary R. ^{[20
]}

Barnwell, John W. ^{[28
]}

Fraser-Liggett, Claire M. ^{[5
,7
]}

机构：

[1] J Craig Venter Inst, Inst Genom Res, Rockville, MD 20850 USA

[2] NYU, Langone Med Ctr, Dept Med Parasitol, New York, NY 10010 USA

[3] Univ S Florida, Coll Publ Hlth, Dept Global Hlth, Tampa, FL 33612 USA

[4] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

[5] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA

[6] Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA

[7] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA

[8] Univ Maryland, Ctr Bioinformat & Computat Biol, College Pk, MD 20742 USA

[9] Australian Army Malaria Inst, Enoggera, Qld 4051, Australia

[10] European Bioinformat Inst, Microarray Grp, Cambridge CB10 1SD, England

[11] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

[12] Burnet Inst, Melbourne, Vic 3004, Australia

[13] Univ Barcelona, Barcelona Ctr Int Hlth Res, Hosp Clin IDIBAPS, E-08036 Barcelona, Spain

[14] Passeig Lluis Co, Inst Catalana Recerca & Estud Avancats, Barcelona 08010, Spain

[15] Univ Penn, Sch Med, Ctr Bioinformat, Philadelphia, PA 19104 USA

[16] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

[17] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

[18] Hood Coll, Frederick, MD 21701 USA

[19] Heidelberg Univ, Sch Med, Dept Parasitol, D-69120 Heidelberg, Germany

[20] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[21] Emory Univ, Emory Vaccine Ctr, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA

[22] Emory Univ, Dept Med, Div Infect Dis, Atlanta, GA 30329 USA

[23] Macquarie Univ, Dept Chem & Biomol Sci, Sydney, NSW 2109, Australia

[24] Univ Melbourne, Dept Biochem & Mol Biol, Bio21 Mol Sci & Biotechnol Inst, Melbourne, Vic 3010, Australia

[25] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia

[26] Univ Sao Paulo, Dept Parasitol, Inst Ciencias Biomed, BR-05508900 Sao Paulo, Brazil

[27] Sanaria Inc, Rockville, MD 20850 USA

[28] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA 30341 USA

来源：

NATURE | 2008年 / 455卷 / 7214期

关键词：

D O I：

10.1038/nature07327

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human malaria parasite Plasmodium vivax is responsible for 25 - 40% of the similar to 515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non- human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species.

引用

页码：757 / 763

页数：8

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