Nanocomposites of 2-arylpropionic acid drugs based on Mg-Al layered double hydroxide for dissolution enhancement

被引：44

作者：

Berber, Mohamed R. ^{[1
]}

Minagawa, Keiji ^{[1
]}

Katoh, Masahiro ^{[1
]}

Mori, Takeshi ^{[2
]}

Tanaka, Masami ^{[3
]}

机构：

[1] Univ Tokushima, Inst Sci & Technol, Tokushima 7708506, Japan

[2] Kyushu Univ, Dept Appl Chem, Nishi Ku, Fukuoka 8190395, Japan

[3] Tokushima Bunri Univ, Fac Pharmaceut Sci, Tokushima 7708514, Japan

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2008年 / 35卷 / 04期

关键词：

Naproxen; Flurbiprofen; LDH; Dissolution rate; Intercalation;

D O I：

10.1016/j.ejps.2008.08.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Naproxen (NP) and flurpibrofen (FB) as non-steroidal anti-inflammatory drugs (NSAIDs) of 2-arylpropionic acid derivatives have been used as host organic drugs to be intercalated into layered double hydroxide (LDH) applying reconstruction and co-precipitation techniques. The obtained NP-LDH and FB-LDH nanocomposites were characterized by X-ray powder diffraction, infrared and thermogravimetric analyses. From drug loading, thermal analysis and X-ray measurements we can decide that coprecipitaion technique is better than reconstruction technique to obtain intercalated monophase nanocomposites. in acidic medium LDH dissolved and the intercalated drug starts to release in a molecular form which is suitable for adsorption. The drug solubility has been investigated before and after intercalation. it has been found that LDH improves the drug solubility and its dissolution rate. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：354 / 360

页数：7

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