Myeloid-Derived Suppressor Cells Mediate Inflammation Resolution in Humans and Mice with Autoimmune Uveoretinitis

被引:21
作者
Jeong, Hyun Jeong [1 ,2 ]
Lee, Hyun Ju [1 ,2 ]
Ko, Jung Hwa [1 ,2 ]
Cho, Bum-Joo [3 ]
Park, Se Yeon [1 ,2 ]
Park, Jong Woo [1 ,2 ]
Choi, Se Rang [1 ]
Heo, Jang Won [1 ]
Yoon, Sun-ok [4 ]
Oh, Joo Youn [1 ,2 ]
机构
[1] Seoul Natl Univ Hosp, Dept Ophthalmol, Seoul 03080, South Korea
[2] Seoul Natl Univ Hosp, Biomed Res Inst, Seoul Artificial Eye Ctr, Lab Ocular Regenerat Med & Immunol, Seoul 03080, South Korea
[3] Hallym Univ, Coll Med, Chuncheon Sacred Heart Hosp, Dept Ophthalmol, Chunchon 24253, Gangwon Do, South Korea
[4] Eutilex Co Ltd, R&D Lab, Seoul 08594, South Korea
关键词
NECK-CANCER; MONOCYTES; PLAY; NEUTROPHILS; MATURATION; HEAD; MDSC;
D O I
10.4049/jimmunol.1700617
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Resolution of inflammation is an active process that leads to tissue homeostasis and involves multiple cellular and molecular mechanisms. Myeloid-derived suppressor cells (MDSCs) have recently emerged as important cellular components in the resolution of inflammation because of their activities to suppress T cell activation. In this article, we show that HLA-DR2CD11b(+)CD33(+) CD14(+) human MDSCs and CD11b(+) Ly6G 2 Ly6C(+) mouse MDSCs markedly increased in patients and mice during and before the resolution phase of autoimmune uveoretinitis. CD11b(+) Ly6C(+) monocytes isolated from autoimmune uveoretinitis mice were able to suppress T cell proliferation in culture, and adoptive transfer of the cells accelerated the remission of autoimmune uveoretinitis in mice. Alternatively, depletion of CD11b(+)Ly6C(+) monocytes at the resolution phase, but not CD11b(+)Ly6G(+) granulocytes, exacerbated the disease. These findings collectively indicate that monocytic MDSCs serve as regulatory cells mediating the resolution of autoimmune uveoretinitis.
引用
收藏
页码:1306 / 1315
页数:10
相关论文
共 40 条
[1]  
Agarwal Rajeev K, 2012, Methods Mol Biol, V900, P443, DOI 10.1007/978-1-60761-720-4_22
[2]  
BUESSOW SC, 1984, JNCI-J NATL CANCER I, V73, P249
[3]   Mir-223 regulates the number and function of myeloid-derived suppressor cells in multiple sclerosis and experimental autoimmune encephalomyelitis [J].
Cantoni, Claudia ;
Cignarella, Francesca ;
Ghezzi, Laura ;
Mikesell, Bob ;
Bollman, Bryan ;
Berrien-Elliott, Melissa M. ;
Ireland, Aaron R. ;
Fehniger, Todd A. ;
Wu, Gregory F. ;
Piccio, Laura .
ACTA NEUROPATHOLOGICA, 2017, 133 (01) :61-77
[4]  
Caspi Rachel R, 2003, Curr Protoc Immunol, VChapter 15, DOI 10.1002/0471142735.im1506s53
[5]   CD15+/CD16low human granulocytes from terminal cancer patients: granulocytic myeloid-derived suppressor cells that have suppressive function [J].
Choi, Jahyang ;
Suh, Beomseok ;
Ahn, Yong-Oon ;
Kim, Tae Min ;
Lee, Jeong-Ok ;
Lee, Se-Hoon ;
Heo, Dae Seog .
TUMOR BIOLOGY, 2012, 33 (01) :121-129
[6]   Expansion and preferential activation of the CD14+CD16+ monocyte subset during multiple sclerosis [J].
Chuluundorj, Delgertsetseg ;
Harding, Scott A. ;
Abernethy, David ;
La Flamme, Anne Camille .
IMMUNOLOGY AND CELL BIOLOGY, 2014, 92 (06) :509-517
[7]   MDSC in autoimmunity [J].
Cripps, James G. ;
Gorham, James D. .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2011, 11 (07) :789-793
[8]   Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice [J].
Daley, Jean M. ;
Thomay, Alan A. ;
Connolly, Michael D. ;
Reichner, Jonathan S. ;
Albina, Jorge E. .
JOURNAL OF LEUKOCYTE BIOLOGY, 2008, 83 (01) :64-70
[9]   Degree, duration, and causes of visual loss in uveitis [J].
Durrani, OM ;
Tehrani, NN ;
Marr, JE ;
Moradi, P ;
Stavrou, P ;
Murray, PI .
BRITISH JOURNAL OF OPHTHALMOLOGY, 2004, 88 (09) :1159-1162
[10]   Uveitis: A potentially blinding disease [J].
Durrani, OM ;
Meads, CA ;
Murray, PI .
OPHTHALMOLOGICA, 2004, 218 (04) :223-236