New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis

被引：511

作者：

Yuan, Ting ^{[1
]}

Yang, Ting ^{[1
]}

Chen, Huan ^{[1
]}

Fu, Danli ^{[1
]}

Hu, Yangyang ^{[1
]}

Wang, Jing ^{[1
]}

Yuan, Qing ^{[1
]}

Yu, Hong ^{[1
]}

Xu, Wenfeng ^{[1
]}

Xie, Xiang ^{[1
]}

机构：

[1] Southwest Med Univ, Sch Basic Med Sci, Luzhou 646000, Sichuan, Peoples R China

来源：

REDOX BIOLOGY | 2019年 / 20卷

关键词：

Atherosclerosis; Diabetes mellitus; Reactive oxygen species; Gut microbiota; MicroRNA; ACTIVATED PROTEIN-KINASE; ENDOPLASMIC-RETICULUM STRESS; SMOOTH-MUSCLE-CELLS; UBIQUITIN-PROTEASOME SYSTEM; ALDOSE REDUCTASE EXPRESSION; C/EBP HOMOLOGOUS PROTEIN; GLYCATION END-PRODUCTS; KAPPA-B-ALPHA; NITRIC-OXIDE; INSULIN-RESISTANCE;

D O I：

10.1016/j.redox.2018.09.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidative stress and inflammation interact in the development of diabetic atherosclerosis. Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species (ROS), increased formation of intracellular advanced glycation end-products, activation of protein kinase C, and increased polyol pathway flux. ROS directly increase the expression of inflammatory and adhesion factors, formation of oxidized-low density lipoprotein, and insulin resistance. They activate the ubiquitin pathway, inhibit the activation of AMP-protein kinase and adiponectin, decrease endothelial nitric oxide synthase activity, all of which accelerate atherosclerosis. Changes in the composition of the gut microbiota and changes in microRNA expression that influence the regulation of target genes that occur in diabetes interact with increased ROS and inflammation to promote atherosclerosis. This review highlights the consequences of the sustained increase of ROS production and inflammation that influence the acceleration of atherosclerosis by diabetes. The potential contributions of changes in the gut microbiota and microRNA expression are discussed.

引用

页码：247 / 260

页数：14

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