Polyelectrolyte Complexes of Natural Polymers and Their Biomedical Applications

被引：90

作者：

Ishihara, Masayuki ^{[1
]}

Kishimoto, Satoko ^{[2
]}

Nakamura, Shingo ^{[1
]}

Sato, Yoko ^{[1
]}

Hattori, Hidemi ^{[3
]}

机构：

[1] Natl Def Med Coll, Div Biomed Engn, Res Inst, Saitama 3598513, Japan

[2] Dokkyo Med Univ, Res Support Ctr, Mibu, Tochigi 3210293, Japan

[3] Univ Miyazaki, Dept Biochem & Appl Sci, Miyazaki 8892162, Japan

来源：

POLYMERS | 2019年 / 11卷 / 04期

关键词：

glycosaminoglycan; chitin; chitosan; polyelectrolyte complexes; cell delivery carrier; drug delivery carriers; FIBROBLAST GROWTH FACTOR-2; PHOTOCROSSLINKED CHITOSAN HYDROGELS; MOLECULAR-WEIGHT HEPARIN; BOVINE SERUM-ALBUMIN; IN-VIVO; CONTROLLED-RELEASE; FRAGMIN/PROTAMINE MICROPARTICLES; SILVER NANOPARTICLES; STRUCTURAL FEATURES; CHONDROITIN SULFATE;

D O I：

10.3390/polym11040672

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Polyelectrolyte complexes (PECs), composed of natural and biodegradable polymers, (such as positively charged chitosan or protamine and negatively charged glycosaminoglycans (GAGs)) have attracted attention as hydrogels, films, hydrocolloids, and nano-/micro-particles (N/MPs) for biomedical applications. This is due to their biocompatibility and biological activities. These PECs have been used as drug and cell delivery carriers, hemostats, wound dressings, tissue adhesives, and scaffolds for tissue engineering. In addition to their comprehensive review, this review describes our original studies and provides an overview of the characteristics of chitosan-based hydrogel, including photo-cross-linkable chitosan hydrogel and hydrocolloidal PECs, as well as molecular-weight heparin (LH)/positively charged protamine (P) N/MPs. These are generated by electrostatic interactions between negatively charged LH and positively charged P together with their potential biomedical applications.

引用

页数：12

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