Prospective Treatment of Age-Related Diseases by Slowing Down Aging

被引：83

作者：

Blagosklonny, Mikhail V. ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept of Cell Stress Biol, Buffalo, NY 14263 USA

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2012年 / 181卷 / 04期

关键词：

GENETICALLY HETEROGENEOUS MICE; RENAL-TRANSPLANT RECIPIENTS; EXTENDS LIFE-SPAN; CELL-CYCLE ARREST; CALORIE RESTRICTION; INSULIN-RESISTANCE; MTOR INHIBITOR; ORAL RAPAMYCIN; SENESCENCE; HUMANS;

D O I：

10.1016/j.ajpath.2012.06.024

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Atherosclerosis, hypertension, obesity, diabetic complications, cancer, benign prostate hyperplasia, Alzheimer and Parkinson diseases, age-related macular degeneration, osteoarthritis, osteoporosis, and seborrheic keratosis are strongly associated with aging, implying a common underlying process. Each disease is treated separately and, in most cases, symptomatically. Suppression of aging itself should delay or treat all age-related diseases, thus increasing healthy life span and maximal longevity. But, is it possible to slow down aging? Recent evidence indicates that the target of rapamycin signaling pathway is involved in cellular senescence and organismal aging. Preclinical and clinical studies demonstrated the therapeutic effects of rapamycin in diverse age-related diseases. One simple reason why a single drug is indicated for so many age-related diseases is that it inhibits the aging process. (Am J Pathol 2012, 181:1142-1146; http://dx.doi.org/10.1016/j.ajpath.2012.06.024)

引用

页码：1142 / 1146

页数：5

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