Circular RNA: An emerging non-coding RNA as a regulator and biomarker in cancer

被引：256

作者：

Chen, Bing ^{[1
,2
,3
]}

Huang, Shenglin ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Shanghai Canc Ctr, Shanghai 200032, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, Shanghai 200032, Peoples R China

[3] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China

来源：

CANCER LETTERS | 2018年 / 418卷

基金：

中国国家自然科学基金;

关键词：

Circular RNA; Cancer; Noncoding RNA; MicroRNA; Biomarker; PROMOTES CELL-PROLIFERATION; GASTRIC-CANCER; DECREASED EXPRESSION; COLORECTAL-CANCER; INVASION; REVEALS; MIGRATION; GROWTH; TRANSLATION; PROGRESSION;

D O I：

10.1016/j.canlet.2018.01.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circular RNA (circRNA) is a type of covalently closed non-coding RNA that may regulate gene expression in eukaryotes. The recent application of high-throughput RNA sequencing and bioinformatics approaches has revealed a large number of circRNAs in human cells. Emerging evidence indicates that many circRNAs have cell-type specific expression and are linked to physiological development and various diseases. Specially, circRNAs can either serve as oncogenic stimuli or tumor suppressors in cancer. circRNAs have also been shown to be enriched and stable in extracellular fluid, indicating the potential of circRNAs as cancer biomarkers. Here, we summarize the current knowledge of circRNAs, including their classification, biogenesis, properties, and databases, as well as their function and clinical implications in cancer. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：41 / 50

页数：10

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