Extracellular vesicles: Novel mediator for cell to cell communications in liver pathogenesis

被引：83
|
作者：
Devhare, Pradip B. [1 ]
Ray, Ratna B. [1 ]
机构：
[1] St Louis Univ, Dept Pathol, DRC 207,1100 South Grand Blvd, St Louis, MO 63104 USA
来源：
MOLECULAR ASPECTS OF MEDICINE | 2018年 / 60卷
基金：
美国国家卫生研究院;
关键词：
Extracellular vesicles; Exosomes; Liver; NAFLD; NASH; HCC; HEPATITIS-C VIRUS; TISSUE GROWTH-FACTOR; STELLATE CELLS; EXOSOMAL MICRORNAS; BIOMARKERS; HEPATOCYTE; RELEASE; RNA; MICROVESICLES; EXPRESSION;
D O I：
10.1016/j.mam.2017.11.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Extracellular vesicles (EVs) are membrane derived nanometer-sized vesicles. EVs are released by normal, diseased, and transformed cells in vitro and in vivo, and carry lipids, proteins, mRNAs, non-coding RNAs, and even DNA out of cells. Transferring biological information via EVs to neighboring cells and intercellular communication not only maintain physiological functions, but also involve in the pathogenesis of several diseases, including cancer. The aim of this review is to discuss the emerging role of EVs in viral hepatitis, non-alcoholic or alcoholic liver disease and liver cancers. We summarize what is known about exosome biogenesis, and role in liver disease progression, and discuss the potential clinical applications of EVs as predictive biomarkers and therapeutic modalities. (c) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：115 / 122
页数：8
相关论文
共 50 条
  • [41] Extracellular vesicles participate in the pathogenesis of sepsis
    Tian, Chang
    Wang, Ke
    Zhao, Min
    Cong, Shan
    Di, Xin
    Li, Ranwei
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2022, 12
  • [42] Role of Extracellular Vesicles in Autoimmune Pathogenesis
    Wu, Wen-Cheng
    Song, Sheng-Jiao
    Zhang, Yuan
    Li, Xing
    FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [43] Deciphering Fungal Extracellular Vesicles: From Cell Biology to Pathogenesis
    Vanessa K. A. Silva
    Marcio L. Rodrigues
    Robin C. May
    Current Clinical Microbiology Reports, 2019, 6 : 89 - 97
  • [44] Deciphering Fungal Extracellular Vesicles: From Cell Biology to Pathogenesis
    Silva, Vanessa K. A.
    Rodrigues, Marcio L.
    May, Robin C.
    CURRENT CLINICAL MICROBIOLOGY REPORTS, 2019, 6 (03) : 89 - 97
  • [45] Pathogenesis and interaction of neutrophils and extracellular vesicles in noncancer liver diseases
    Sun, Jie
    Yang, Fan
    Zheng, Yanyi
    Huang, Chen
    Fan, Xiaoli
    Yang, Li
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 137
  • [46] Subtypes of tumour cell-derived small extracellular vesicles having differently externalized phosphatidylserine
    Matsumura, Sachiko
    Minamisawa, Tamiko
    Suga, Kanako
    Kishita, Hiromi
    Akagi, Takanori
    Ichiki, Takanori
    Ichikawa, Yuki
    Shiba, Kiyotaka
    JOURNAL OF EXTRACELLULAR VESICLES, 2019, 8 (01):
  • [47] Extracellular Vesicles in Non-alcoholic Fatty Liver Disease and Alcoholic Liver Disease
    Wu, Dongqing
    Zhu, Huaqing
    Wang, Hua
    FRONTIERS IN PHYSIOLOGY, 2021, 12
  • [48] Extracellular Vesicles: A New Frontier in Biomarker Discovery for Non-Alcoholic Fatty Liver Disease
    Ban, Linda A.
    Shackel, Nicholas A.
    McLennan, Susan V.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (03):
  • [49] Immune Cell-Derived Extracellular Vesicles in the Face of Pathogenic Infections
    Keshtkar, Somayeh
    Soleimanian, Saeede
    Kaviani, Maryam
    Sarvestani, Fatemeh Sabet
    Azarpira, Negar
    Asvar, Zahra
    Pakbaz, Sara
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [50] Extracellular vesicles: catching the light of intercellular communication in fibrotic liver diseases
    Li, Yijie
    Wu, Jianzhi
    Liu, Runping
    Zhang, Yinhao
    Li, Xiaojiaoyang
    THERANOSTICS, 2022, 12 (16): : 6955 - 6971
12345