Extracellular vesicles: Novel mediator for cell to cell communications in liver pathogenesis

被引：83
|
作者：
Devhare, Pradip B. [1 ]
Ray, Ratna B. [1 ]
机构：
[1] St Louis Univ, Dept Pathol, DRC 207,1100 South Grand Blvd, St Louis, MO 63104 USA
来源：
MOLECULAR ASPECTS OF MEDICINE | 2018年 / 60卷
基金：
美国国家卫生研究院;
关键词：
Extracellular vesicles; Exosomes; Liver; NAFLD; NASH; HCC; HEPATITIS-C VIRUS; TISSUE GROWTH-FACTOR; STELLATE CELLS; EXOSOMAL MICRORNAS; BIOMARKERS; HEPATOCYTE; RELEASE; RNA; MICROVESICLES; EXPRESSION;
D O I：
10.1016/j.mam.2017.11.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Extracellular vesicles (EVs) are membrane derived nanometer-sized vesicles. EVs are released by normal, diseased, and transformed cells in vitro and in vivo, and carry lipids, proteins, mRNAs, non-coding RNAs, and even DNA out of cells. Transferring biological information via EVs to neighboring cells and intercellular communication not only maintain physiological functions, but also involve in the pathogenesis of several diseases, including cancer. The aim of this review is to discuss the emerging role of EVs in viral hepatitis, non-alcoholic or alcoholic liver disease and liver cancers. We summarize what is known about exosome biogenesis, and role in liver disease progression, and discuss the potential clinical applications of EVs as predictive biomarkers and therapeutic modalities. (c) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：115 / 122
页数：8
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