Extracellular vesicles: Novel mediator for cell to cell communications in liver pathogenesis

被引：87
作者：
Devhare, Pradip B. [1 ]
Ray, Ratna B. [1 ]
机构：
[1] St Louis Univ, Dept Pathol, DRC 207,1100 South Grand Blvd, St Louis, MO 63104 USA
来源：
MOLECULAR ASPECTS OF MEDICINE | 2018年 / 60卷
基金：
美国国家卫生研究院;
关键词：
Extracellular vesicles; Exosomes; Liver; NAFLD; NASH; HCC; HEPATITIS-C VIRUS; TISSUE GROWTH-FACTOR; STELLATE CELLS; EXOSOMAL MICRORNAS; BIOMARKERS; HEPATOCYTE; RELEASE; RNA; MICROVESICLES; EXPRESSION;
D O I：
10.1016/j.mam.2017.11.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Extracellular vesicles (EVs) are membrane derived nanometer-sized vesicles. EVs are released by normal, diseased, and transformed cells in vitro and in vivo, and carry lipids, proteins, mRNAs, non-coding RNAs, and even DNA out of cells. Transferring biological information via EVs to neighboring cells and intercellular communication not only maintain physiological functions, but also involve in the pathogenesis of several diseases, including cancer. The aim of this review is to discuss the emerging role of EVs in viral hepatitis, non-alcoholic or alcoholic liver disease and liver cancers. We summarize what is known about exosome biogenesis, and role in liver disease progression, and discuss the potential clinical applications of EVs as predictive biomarkers and therapeutic modalities. (c) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：115 / 122
页数：8
相关论文
共 87 条
[61]   Knockdown of Autophagy Inhibits Infectious Hepatitis C Virus Release by the Exosomal Pathway [J].
Shrivastava, Shubham ;
Devhare, Pradip ;
Sujijantarat, Nanthiya ;
Steele, Robert ;
Kwon, Young-Chan ;
Ray, Ranjit ;
Ray, Ratna B. .
JOURNAL OF VIROLOGY, 2016, 90 (03) :1387-1396
[62]   Up-Regulation of Circulating miR-20a Is Correlated With Hepatitis C Virus-Mediated Liver Disease Progression [J].
Shrivastava, Shubham ;
Petrone, Jessica ;
Steele, Robert ;
Lauer, Georg M. ;
Di Bisceglie, Adrian M. ;
Ray, Ratna B. .
HEPATOLOGY, 2013, 58 (03) :863-871
[63]   Injured hepatocyte-released microvesicles induce bone marrow-derived mononuclear cells differentiation [J].
Simon, Laura ;
Lopez, Monica ;
Uribe-Cruz, Carolina ;
Peralvo Vergara, Davi Fernandes ;
Silla, Lucia ;
Matte, Ursula .
DIFFERENTIATION, 2015, 90 (1-3) :40-47
[64]   Exosomes - vesicular carriers for intercellular communication [J].
Simons, Mikael ;
Raposo, Graca .
CURRENT OPINION IN CELL BIOLOGY, 2009, 21 (04) :575-581
[65]   Serum exosomal microRNAs as novel biomarkers for hepatocellular carcinoma [J].
Sohn, Won ;
Kim, Jonghwa ;
Kang, So Hee ;
Yang, Se Ra ;
Cho, Ju-Yeon ;
Cho, Hyun Chin ;
Shim, Sang Goon ;
Paik, Yong-Han .
EXPERIMENTAL AND MOLECULAR MEDICINE, 2015, 47 :e184-e184
[66]   Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation [J].
Sugimachi, K. ;
Matsumura, T. ;
Hirata, H. ;
Uchi, R. ;
Ueda, M. ;
Ueo, H. ;
Shinden, Y. ;
Iguchi, T. ;
Eguchi, H. ;
Shirabe, K. ;
Ochiya, T. ;
Maehara, Y. ;
Mimori, K. .
BRITISH JOURNAL OF CANCER, 2015, 112 (03) :532-538
[67]   Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets [J].
Szabo, Gyongyi ;
Momen-Heravi, Fatemeh .
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2017, 14 (08) :455-466
[68]   Involvement of Extracellular Vesicle Long Noncoding RNA (linc-VLDLR) in Tumor Cell Responses to Chemotherapy [J].
Takahashi, Kenji ;
Yan, Irene K. ;
Wood, Joseph ;
Haga, Hiroaki ;
Patel, Tushar .
MOLECULAR CANCER RESEARCH, 2014, 12 (10) :1377-1387
[69]   Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer [J].
Takahashi, Kenji ;
Yan, Irene K. ;
Kogure, Takayuki ;
Haga, Hiroaki ;
Patel, Tushar .
FEBS OPEN BIO, 2014, 4 :458-467
[70]   Modulation of hypoxia-signaling pathways by extracellular linc-RoR [J].
Takahashi, Kenji ;
Yan, Irene K. ;
Haga, Hiroaki ;
Patel, Tushar .
JOURNAL OF CELL SCIENCE, 2014, 127 (07) :1585-1594
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