D-Serine: physiology and pathology

被引：31

作者：

Radzishevsky, Inna ^{[1
]}

Sason, Hagit ^{[1
]}

Wolosker, Herman ^{[1
]}

机构：

[1] Technion Israel Inst Technol, B Rappaport Fac Med, Dept Biochem, IL-31096 Haifa, Israel

来源：

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE | 2013年 / 16卷 / 01期

基金：

以色列科学基金会;

关键词：

D-serine; gliotransmission; NMDA receptors; RACEMASE;

D O I：

10.1097/MCO.0b013e32835a3466

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review Here, we discuss the recent data on the role of different N-methyl D-aspartate receptor (NMDAR) coagonists, D-serine and glycine, in regulating NMDAR activity and neurotoxicity. Recent findings D-Serine originates from both neurons and astrocytes, from where it is released by different mechanisms. Recent data indicate that like glial D-serine, neuronal D-serine is required for NMDAR-dependent, long-term potentiation at the hippocampal CA1-CA3 synapses and proper synapse formation in the cerebral cortex. D-serine is the physiological coagonist of synaptic NMDAR, whereas glycine action is restricted to extrasynaptic sites. Summary D-Serine is now recognized as the major NMDAR coagonist at the synapse. The data establish D-serine as a key transmitter or neuromodulator that mediates synaptic NMDAR activation and neurotoxicity. In this context, drugs that inhibit D-serine synthesis or release will provide new neuroprotective strategy.

引用

页码：72 / 75

页数：4

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