What can we learn from blood granulocyte patterns in patients with asthma?

被引：3

作者：

Hambleton, Kirsty ^{[1
]}

Pavord, Ian D. ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Med, Resp Med Unit, NDM Res Bldg,Old Rd Campus, Oxford OX3 7FZ, England

来源：

EUROPEAN RESPIRATORY JOURNAL | 2016年 / 48卷 / 04期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; EOSINOPHILIC ASTHMA; INFLAMMATION; PLACEBO; COUNTS; ADULTS; COPD;

D O I：

10.1183/13993003.01567-2016

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

引用

页码：976 / 978

页数：3

共 16 条

[1] Treatable traits: toward precision medicine of chronic airway diseases [J].

Agusti, Alvar ;

Bel, Elisabeth ;

Thomas, Mike ;

Vogelmeier, Claus ;

Brusselle, Guy ;

Holgate, Stephen ;

Humbert, Marc ;

Jones, Paul ;

Gibson, Peter G. ;

Vestbo, Jorgen ;

Beasley, Richard ;

Pavord, Ian D. .

EUROPEAN RESPIRATORY JOURNAL, 2016, 47 (02) :410-419

[2]

Castro M, 2015, LANCET RESP MED, V3, P355, DOI [10.1016/S2213-2600(15)00042-9, 10.1016/S2213-2600(15)00119-8]

[3] Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study [J].

Castro, Mario ;

Wenzel, Sally E. ;

Bleecker, Eugene R. ;

Pizzichini, Emilio ;

Kuna, Piotr ;

Busse, William W. ;

Gossage, David L. ;

Ward, Christine K. ;

Wu, Yanping ;

Wang, Bing ;

Khatry, Deepak B. ;

van der Merwe, Rene ;

Kolbeck, Roland ;

Molfino, Nestor A. ;

Raible, Donald G. .

LANCET RESPIRATORY MEDICINE, 2014, 2 (11) :879-890

[4] Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects [J].

Malinovschi, Andrei ;

Fonseca, Joao A. ;

Jacinto, Tiago ;

Alving, Kjell ;

Janson, Christer .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 132 (04) :821-+

[5] Blood granulocyte patterns as predictors of asthma phenotypes in adults from the EGEA study [J].

Nadif, Rachel ;

Siroux, Valerie ;

Boudier, Anne ;

le Moual, Nicole ;

Just, Jocelyne ;

Gormand, Frederic ;

Pison, Christophe ;

Matran, Regis ;

Pin, Isabelle .

EUROPEAN RESPIRATORY JOURNAL, 2016, 48 (04) :1040-1051

[6] Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials [J].

Pascoe, Steven ;

Locantore, Nicholas ;

Dransfield, Mark T. ;

Barnes, Neil C. ;

Pavord, Ian D. .

LANCET RESPIRATORY MEDICINE, 2015, 3 (06) :435-442

[7] Blood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPD [J].

Pavord, Ian D. ;

Lettis, Sally ;

Locantore, Nicholas ;

Pascoe, Steve ;

Jones, Paul W. ;

Wedzicha, Jadwiga A. ;

Barnes, Neil C. .

THORAX, 2016, 71 (02) :118-125

[8] Biomarkers and inhaled corticosteroid responsiveness in asthmatic patients [J].

Pavord, Ian D. ;

Hilvering, Bart .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2015, 135 (04) :884-885

[9] Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial [J].

Pavord, Ian D. ;

Korn, Stephanie ;

Howarth, Peter ;

Bleecker, Eugene R. ;

Buhl, Roland ;

Keene, Oliver N. ;

Ortega, Hector ;

Chanez, Pascal .

LANCET, 2012, 380 (9842) :651-659

[10] Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study [J].

Price, David B. ;

Rigazio, Anna ;

Campbell, Jonathan D. ;

Bleecker, Eugene R. ;

Corrigan, Christopher J. ;

Thomas, Mike ;

Wenzel, Sally E. ;

Wilson, Andrew M. ;

Small, Mary Buatti ;

Gopalan, Gokul ;

Ashton, Valerie L. ;

Burden, Anne ;

Hillyer, Elizabeth V. ;

Kerkhof, Marian ;

Pavord, Ian D. .

LANCET RESPIRATORY MEDICINE, 2015, 3 (11) :849-858

← 1 2 →