NANOEMULSIONS AS PARENTERAL DRUG DELIVERY SYSTEMS

被引：66

作者：

Bruxel, Fernanda ^{[1
]}

Laux, Manoela ^{[1
]}

Wild, Luisa Bartmann ^{[1
]}

Fraga, Michelle ^{[1
]}

Koester, Leticia S. ^{[1
]}

Teixeira, Helder F. ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Fac Farm, BR-90610000 Porto Alegre, RS, Brazil

来源：

QUIMICA NOVA | 2012年 / 35卷 / 09期

关键词：

emulsion; parenteral; drug; OIL-IN-WATER; SUBMICRON LIPID EMULSION; VITRO RELEASE; PHYSICOCHEMICAL PROPERTIES; INTRAVENOUS EMULSION; PROSTAGLANDIN E(1); O/W-EMULSION; INJECTABLE EMULSIONS; TISSUE DISTRIBUTION; RICH NANOEMULSION;

D O I：

10.1590/S0100-40422012000900023

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

NANOEMULSIONS AS PARENTERAL DRUG DELIVERY SYSTEMS. Lipid nanoemulsions have recently been proposed as parenteral delivery systems for poorly-soluble drugs. These systems consist of nanoscale oil/water dispersions stabilized by an appropriate surfactant system in which the drug is incorporated into the oil core and/or adsorbed at the interface. This article reviews technological aspects of such nanosystems, including their composition, preparation methods, and physicochemical properties. From this review, it was possible to identify five groups of nanoemulsions based on their composition. Biopharmaceutical aspects of formulations containing some commercially available drugs (diazepam, propofol, dexamethasone, etomidate, flurbiprofen and prostaglandin E1) were then discussed.

引用

页码：1827 / 1840

页数：14

共 157 条

[71]

2-7

[72] Microemulsion-based media as novel drug delivery systems [J].

Lawrence, MJ ;

Rees, GD .

ADVANCED DRUG DELIVERY REVIEWS, 2000, 45 (01) :89-121

[73] DESIGN AND CHARACTERIZATION OF A SUBMICRONIZED O/W EMULSION OF DIAZEPAM FOR PARENTERAL USE [J].

LEVY, MY ;

BENITA, S .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1989, 54 (02) :103-112

[74] EFFICACY EVALUATION OF A NOVEL SUBMICRON MICONAZOLE EMULSION IN A MURINE CRYPTOCOCCOSIS MODEL [J].

LEVY, MY ;

POLACHECK, I ;

BARENHOLZ, Y ;

BENITA, S .

PHARMACEUTICAL RESEARCH, 1995, 12 (02) :223-230

[75] Optimization of tocol emulsions for the intravenous delivery of clarithromycin [J].

Li, He ;

Nie, Shufang ;

Yang, Xingang ;

Wang, Changguang ;

Cui, Shuxia ;

Pan, Weisan .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 356 (1-2) :282-290

[76] LONG-CIRCULATING EMULSIONS (OIL-IN-WATER) AS CARRIERS FOR LIPOPHILIC DRUGS [J].

LIU, F ;

LIU, D .

PHARMACEUTICAL RESEARCH, 1995, 12 (07) :1060-1064

[77] STABILITY OF A LESS-PAINFUL INTRAVENOUS EMULSION OF CLARITHROMYCIN [J].

LOVELL, MW ;

JOHNSON, HW ;

GUPTA, PK .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1995, 118 (01) :47-54

[78] Formulation and thermal sterile stability of a less painful intravenous clarithromycin emulsion containing vitamin E [J].

Lu, Yan ;

Wang, YanJiao ;

Tang, Xing .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 346 (1-2) :47-56

[79] Formulation of an intravenous emulsion loaded with a clarithromycin-phospholipid complex and its pharmacokinetics in rats [J].

Lu, Yan ;

Zhang, Yu ;

Yang, Ziyi ;

Tang, Xing .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2009, 366 (1-2) :160-169

[80] A lipophilic paclitaxel derivative incorporated in a lipid emulsion for parenteral administration [J].

Lundberg, BB ;

Risovic, V ;

Ramaswamy, M ;

Wasan, KM .

JOURNAL OF CONTROLLED RELEASE, 2003, 86 (01) :93-100

← 3 4 5 6 7 8 9 10 11 12 →