Molecular and spatial epidemiology of HCV among people who inject drugs in Boston, Massachusetts

被引：1

作者：

Stopka, Thomas J. ^{[1
]}

Yaghi, Omar ^{[1
]}

Li, Min ^{[2
]}

Paintsil, Elijah ^{[2
,3
]}

Chui, Kenneth ^{[1
]}

Landy, David ^{[1
]}

Heimer, Robert ^{[2
,4
]}

机构：

[1] Tufts Univ, Sch Med, Dept Publ Hlth & Community Med, Boston, MA 02111 USA

[2] Yale Univ, Sch Med, New Haven, CT 06536 USA

[3] Yale Univ, Sch Publ Hlth, New Haven, CT USA

[4] Ctr Interdisciplinary Res AIDS Yale, New Haven, CT 06510 USA

来源：

PLOS ONE | 2022年 / 17卷 / 08期

关键词：

HEPATITIS-C VIRUS; UNITED-STATES; INFECTIONS;

D O I：

10.1371/journal.pone.0266216

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Integration of genetic, social network, and spatial data has the potential to improve understanding of transmission dynamics in established HCV epidemics. Sequence data were analyzed from 63 viremic people who inject drugs recruited in the Boston area through chain referral or time-location sampling. HCV subtype 1a was most prevalent (57.1%), followed by subtype 3a (33.9%). The phylogenetic distances between sequences were no shorter comparing individuals within versus across networks, nor by location or time of first injection. Social and spatial networks, while interesting, may be too ephemeral to inform transmission dynamics when the date and location of infection are indeterminate.

引用

页数：9

共 19 条

[11] Hepatitis C virus infection among drug injectors in St Petersburg, Russia: social and molecular epidemiology of an endemic infection [J].

Paintsil, Elijah ;

Verevochkin, Sergei V. ;

Dukhovlinova, Elena ;

Niccolai, Linda ;

Barbour, Russell ;

White, Edward ;

Toussova, Olga V. ;

Alexander, Louis ;

Kozlov, Andrei P. ;

Heimer, Robert .

ADDICTION, 2009, 104 (11) :1881-1890

[12] A large HCV transmission network enabled a fast-growing HIV outbreak in rural Indiana, 2015 [J].

Ramachandran, Sumathi ;

Thai, Hong ;

Forbi, Joseph C. ;

Galang, Romeo Regi ;

Dimitrova, Zoya ;

Xia, Guo-liang ;

Lin, Yulin ;

Punkova, Lili T. ;

Pontones, Pamela R. ;

Gentry, Jessica ;

Blosser, Sara J. ;

Lovchik, Judith ;

Switzer, William M. ;

Teshale, Eyasu ;

Peters, Philip ;

Ward, John ;

Khudyakov, Yury .

EBIOMEDICINE, 2018, 37 :374-381

[13] Risk environments and drug harms: A social science for harm reduction approach [J].

Rhodes, Tim .

INTERNATIONAL JOURNAL OF DRUG POLICY, 2009, 20 (03) :193-201

[14] The Atlanta Urban Networks Study: a blueprint for endemic transmission [J].

Rothenberg, RB ;

Long, DM ;

Sterk, CE ;

Pach, A ;

Potterat, JJ ;

Muth, S ;

Baldwin, JA ;

Trotter, RT .

AIDS, 2000, 14 (14) :2191-2200

[15] Hepatitis C Virus Phylogenetic Clustering Is Associated with the Social-Injecting Network in a Cohort of People Who Inject Drugs [J].

Sacks-Davis, Rachel ;

Daraganova, Galina ;

Aitken, Campbell ;

Higgs, Peter ;

Tracy, Lilly ;

Bowden, Scott ;

Jenkinson, Rebecca ;

Rolls, David ;

Pattison, Philippa ;

Robins, Garry ;

Grebely, Jason ;

Barry, Alyssa ;

Hellard, Margaret .

PLOS ONE, 2012, 7 (10)

[16] The association of hepatitis C prevalence, activity, and genotype with HIV infection in a cohort of New York City drug users [J].

Strasfeld, L ;

Lo, YT ;

Netski, D ;

Thomas, TL ;

Klein, TS .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2003, 33 (03) :356-364

[17] Emerging Epidemic of Hepatitis C Virus Infections Among Young Nonurban Persons Who Inject Drugs in the United States, 2006-2012 [J].

Suryaprasad, Anil G. ;

White, Jianglan Z. ;

Xu, Fujie ;

Eichler, Beth-Ann ;

Hamilton, Janet ;

Patel, Ami ;

Hamdounia, Shadia Bel ;

Church, Daniel R. ;

Barton, Kerri ;

Fisher, Charde ;

Macomber, Kathryn ;

Stanley, Marisa ;

Guilfoyle, Sheila M. ;

Sweet, Kristin ;

Liu, Stephen ;

Iqbal, Kashif ;

Tohme, Rania ;

Sharapov, Umid ;

Kupronis, Benjamin A. ;

Ward, John W. ;

Holmberg, Scott D. .

CLINICAL INFECTIOUS DISEASES, 2014, 59 (10) :1411-1419

[18] MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods [J].

Tamura, Koichiro ;

Peterson, Daniel ;

Peterson, Nicholas ;

Stecher, Glen ;

Nei, Masatoshi ;

Kumar, Sudhir .

MOLECULAR BIOLOGY AND EVOLUTION, 2011, 28 (10) :2731-2739

[19] Human Immunodeficiency Virus (HIV) Outbreak Investigation Among Persons Who Inject Drugs in Massachusetts Enhanced by HIV Sequence Data [J].

Tumpney, Matthew ;

John, Betsey ;

Panneer, Nivedha ;

McClung, R. Paul ;

Campbell, Ellsworth M. ;

Roosevelt, Kathleen ;

DeMaria, Alfred ;

Buchacz, Kate ;

Switzer, William M. ;

Lyss, Sheryl ;

Cranston, Kevin .

JOURNAL OF INFECTIOUS DISEASES, 2020, 222 :S259-S267

← 1 2 →