The Use of Tertiary Alkylmagnesium Nucleophiles in Ni-Catalyzed Cross-Coupling Reactions

被引：17

作者：

Joshi-Pangu, Amruta ^{[1
]}

Biscoe, Mark R. ^{[1
]}

机构：

[1] CUNY City Coll, Dept Chem, New York, NY 10031 USA

来源：

SYNLETT | 2012年 / 08期

关键词：

nickel; cross-coupling; transition metals; homogeneous catalysis; Grignard reaction; GRIGNARD-REAGENTS; LIGAND; HALIDES; SELECTIVITIES; ARYLATION;

D O I：

10.1055/s-0031-1290765

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nickel-catalyzed cross-coupling reactions of unactivated tertiary alkyl nucleophiles and aryl bromides have been developed using N-heterocyclic carbene ligands. These processes are reviewed alongside earlier attempts to employ unactivated tertiary alkyl nucleophiles in cross-coupling reactions. Potential mechanisms for the transformations, and future challenges in this field are discussed.

引用

页码：1103 / 1107

页数：5

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