Convenient one-pot heterogeneous catalytic method for the preparation of 3,4-dihydropyrimidin-2(1H)-ones

被引：32

作者：

Hegedüs, A ^{[1
]}

Hell, Z ^{[1
]}

Vígh, I ^{[1
]}

机构：

[1] Budapest Univ Technol & Econ, Dept Organ Chem Technol, H-1521 Budapest, Hungary

来源：

SYNTHETIC COMMUNICATIONS | 2006年 / 36卷 / 01期

关键词：

Biginelli reaction; green chemistry; heterocycles; multicomponent reaction; zeolites;

D O I：

10.1080/00397910500330858

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new, simple, environmentally friendly synthesis of dihydropyrimidinones from aromatic and aliphatic aldehydes, ethyl acetoacetate, and urea or thiourea using a small-pore-size zeolite as catalyst is described. Compared with the classical Biginelli reaction conditions, this method has the advantage of high yield, shorter reaction time, and recyclable and reusable catalyst.

引用

页码：129 / 136

页数：8

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