CLEAN AND CONVENIENT ONE-POT SYNTHESIS OF 4-HYDROXYCOUMARIN AND 4-HYDROXY-2-QUINOLINONE DERIVATIVES

被引：66
作者：
Gao, Wen-Tao [1 ]
Hou, Wen-Duan [1 ]
Zheng, Mei-Ru [1 ]
Tang, Li-Jun [1 ]
机构：
[1] Bohai Univ, Coll Chem & Chem Engn, Jinzhou 12100, Liaoning, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 05期
关键词：
Eaton's reagent; 4-hydroxycoumarin; 4-hydroxy-2-quinolinone; one-pot; QUINOLINE ALKALOIDS; GLYCINE-SITE; EFFICIENT SYNTHESIS; ANTAGONISTS; RECEPTORS; NMDA;
D O I：
10.1080/00397910903013713
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, efficient, and environmentally friendly procedure has been developed for the reaction of Meldrum's acid with phenol, substituted phenols, aniline, or substituted anilines with Eaton's reagent (phosphoric anhydride+methylsulfonic acid) as cyclization reagent. 4-Hydroxycoumarins and 4-hydroxy-2-quinolinones were synthesized in moderate yields by carrying out the reaction in solvent-free, convenient, and clean one-pot preparation.
引用
收藏
页码：732 / 738
页数：7
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