CLEAN AND CONVENIENT ONE-POT SYNTHESIS OF 4-HYDROXYCOUMARIN AND 4-HYDROXY-2-QUINOLINONE DERIVATIVES

被引：68

作者：

Gao, Wen-Tao ^{[1
]}

Hou, Wen-Duan ^{[1
]}

Zheng, Mei-Ru ^{[1
]}

Tang, Li-Jun ^{[1
]}

机构：

[1] Bohai Univ, Coll Chem & Chem Engn, Jinzhou 12100, Liaoning, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 05期

关键词：

Eaton's reagent; 4-hydroxycoumarin; 4-hydroxy-2-quinolinone; one-pot; QUINOLINE ALKALOIDS; GLYCINE-SITE; EFFICIENT SYNTHESIS; ANTAGONISTS; RECEPTORS; NMDA;

D O I：

10.1080/00397910903013713

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, efficient, and environmentally friendly procedure has been developed for the reaction of Meldrum's acid with phenol, substituted phenols, aniline, or substituted anilines with Eaton's reagent (phosphoric anhydride+methylsulfonic acid) as cyclization reagent. 4-Hydroxycoumarins and 4-hydroxy-2-quinolinones were synthesized in moderate yields by carrying out the reaction in solvent-free, convenient, and clean one-pot preparation.

引用

页码：732 / 738

页数：7

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