Polyketides from Alternaria alternata MT-47, an endophytic fungus isolated from Huperzia serrata

被引：17

作者：

Yang, Hongyun ^{[1
]}

Qi, Bowen ^{[1
]}

Ding, Ning ^{[1
]}

Jiang, Fangfang ^{[1
]}

Jia, Fangfang ^{[1
]}

Luo, Yuan ^{[1
]}

Xu, Xiping ^{[1
]}

Wang, Lili ^{[1
]}

Zhu, Zhixiang ^{[1
]}

Liu, Xiao ^{[1
]}

Tu, Pengfei ^{[1
]}

Shi, Shepo ^{[1
,2
]}

机构：

[1] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China

[2] Beijing Univ Chinese Med, Beijing Key Lab Qual Evaluat Chinese Meteria Med, Beijing 100029, Peoples R China

来源：

FITOTERAPIA | 2019年 / 137卷

基金：

中国国家自然科学基金;

关键词：

Alternaria alternate; Endophytic fungus; Huperzia serrata; Polyketides; Anti-platelet activity; PENICILLIUM-CHRYSOGENUM MT-12; STRUCTURE ELUCIDATION; METABOLITES; DERIVATIVES; ACID; MEROTERPENOIDS; ALTENUSIN; SP;

D O I：

10.1016/j.fitote.2019.104282

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new polyketides, alternatains A-D (1-4), along with 17 known compounds (5-21) were obtained from the solid substrate fermentation cultures of Alternaria alternate MT-47, an endophytic fungus isolated from the medicinal plant of Huperzia serrate. Their structures were elucidated by extensive spectroscopic and spectrometric techniques (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism (ECD) method. Compounds 4, 6, 15, and 21 exhibited inhibitory activities on ATP release of thrombin-activated platelets with IC50 values in the range of 18.2-68.8 mu M.

引用

页数：8

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