Genetic Association of Hepatitis C-Related Mixed Cryoglobulinemia: A 10-Year Prospective Study of Asians Treated with Antivirals

被引:6
作者
Chang, Ming-Ling [1 ,2 ]
Chang, Su-Wei [3 ,4 ]
Chen, Shiang-Chi [5 ]
Chien, Rong-Nan [1 ,2 ]
Hsu, Chia-Lin [6 ]
Chang, Ming-Yu [2 ,7 ,8 ]
Fann, Cathy S. J. [6 ]
机构
[1] Chang Gung Mem Hosp, Dept Gastroenterol & Hepatol, Div Hepatol, Taoyuan 333423, Taiwan
[2] Chang Gung Univ, Coll Med, Dept Med, Taoyuan 333423, Taiwan
[3] Chang Gung Univ, Clin Informat & Med Stat Res Ctr, Taoyua 333423, Taiwan
[4] Chang Gung Mem Hosp, Dept Paediat, Div Allergy Asthma & Rheumatol, Taoyuan 333423, Taiwan
[5] Taipei Med Univ, Dept Nursing, Taipei 11031, Taiwan
[6] Acad Sinica, Inst Biomed Sci, Taipei 115024, Taiwan
[7] Chang Gung Childrens Hosp, Div Pediat Neurol Med, Taoyuan 333423, Taiwan
[8] Chang Gung Mem Hosp, Div Pediat, Keelung 20401, Taiwan
来源
VIRUSES-BASEL | 2021年 / 13卷 / 03期
关键词
HCV; mixed cryoglobulinemia; IFNL3; ARNTL; PAI-1;
D O I
10.3390/v13030464
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Genetic profiles of hepatitis C virus (HCV)-associated mixed cryoglobulinemia (MC) in Asians remain elusive. A 10-year prospective cohort study was conducted with 1043 consecutive HCV Ab-positive Taiwanese surveyed with 13 single nucleotide polymorphisms (SNPs). Of 1043, 589 (56.5%) had baseline MC, 934 (89.5%) had positive HCV RNA, 796 completed anti-HCV therapy, and 715 had sustained virological responses (SVRs). SNP associations were surveyed withgenotypic, allelic, trend, permutation and multivariate analyses. At baseline, higher male sex and MC rates were noted in HCV RNA-positive than RNA-negative patients; higher female sex and positive HCV RNA rates but lower HCV RNA levels were noted in patients with than those without MC. Baseline associations were: HLA II-rs9461776 A allele, IFNL3-rs12979860 T allele, SERPINE1-rs6976053 C allele and MC with HCV RNA positivity; IFNL3-rs12979860 C allele, ARNTL-rs6486122 T allele and HCV RNA positivity with baseline MC. In SVR patients, RETN-rs1423096 C allele and SERPINE1-rs6976053 T allele were associated with 24-week and 10-year post-therapy MC, respectively. Conclusions: HCV RNA, IFNL3-rs12979860 and ARNTL-rs6486122 were associated with baseline MC; RETN-rs1423096 and SERPINE1-rs6976053 were associated with short- and long-term post-therapy MC in SVR patients, respectively. Links with HCV RNA and immune-associated SNPs suggest MC an immune reaction to expel HCV.
引用
收藏
页数:11
相关论文
共 39 条
[1]   Protease nexin-1, tPA, and PAI-1 are upregulated in cryoglobulinemic membranoproliferative glomerulonephritis [J].
不详 .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 19 (02) :243-251
[2]   CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].
BENJAMINI, Y ;
HOCHBERG, Y .
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300
[3]   Role of IL28B genotyping in patients with hepatitis C virus-associated mixed cryoglobulinemia and response to PEG-IFN and ribavirin treatment [J].
Boglione, Lucio ;
Cusato, Jessica ;
Allegra, Sarah ;
Cariti, Giuseppe ;
Di Perri, Giovanni ;
D'Avolio, Antonio .
ARCHIVES OF VIROLOGY, 2015, 160 (08) :2009-2017
[4]   Identification of a Novel Hepatitis C Virus Genotype From Punjab, India: Expanding Classification of Hepatitis C Virus Into 8 Genotypes [J].
Borgia, Sergio M. ;
Hedskog, Charlotte ;
Parhy, Bandita ;
Hyland, Robert H. ;
Stamm, Luisa M. ;
Brainard, Diana M. ;
Subramanian, Mani G. ;
McHutchison, John G. ;
Mo, Hongmei ;
Svarovskaia, Evguenia ;
Shafran, Stephen D. .
JOURNAL OF INFECTIOUS DISEASES, 2018, 218 (11) :1722-1729
[5]   Link between plasminogen activator inhibitor-1 and cardiovascular risk in chronic hepatitis C after viral clearance [J].
Chang, Ming-Ling ;
Lin, Yu-sheng ;
Pao, Li-Heng ;
Huang, Hsin-Chih ;
Chiu, Cheng-Tang .
SCIENTIFIC REPORTS, 2017, 7
[6]   Resistin reinforces interferon λ-3 to eliminate hepatitis C virus with fine-tuning from RETN single-nucleotide polymorphisms [J].
Chang, Ming-Ling ;
Liang, Kung-Hao ;
Ku, Cheng-Lung ;
Lo, Chia-Chi ;
Cheng, Ya-Ting ;
Hsu, Chen-Ming ;
Yeh, Chau-Ting ;
Chiu, Cheng-Tang .
SCIENTIFIC REPORTS, 2016, 6
[7]   Metabolic alterations and hepatitis C: From bench to bedside [J].
Chang, Ming-Ling .
WORLD JOURNAL OF GASTROENTEROLOGY, 2016, 22 (04) :1461-1476
[8]   Rheumatoid factor and immunoglobulin M mark hepatitis C-associated mixed cryoglobulinaemia: an 8-year prospective study [J].
Cheng, Y-T ;
Cheng, J-S ;
Lin, C-H ;
Chen, T-H ;
Lee, K-C ;
Chang, M-L .
CLINICAL MICROBIOLOGY AND INFECTION, 2020, 26 (03) :366-372
[9]   Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia [J].
Cusato, Jessica ;
Boglione, Lucio ;
De Nicolo, Amedeo ;
Cardellino, Chiara Simona ;
Carcieri, Chiara ;
Cariti, Giuseppe ;
Di Perri, Giovanni ;
D'Avolio, Antonio .
PHARMACOGENOMICS, 2017, 18 (07) :607-611
[10]   Resistin Promotes Thrombosis in Rats with Deep Vein Thrombosis via Up-Regulating MMP-2, MMP-9, and PAI-1 [J].
Din, Yang ;
Li, Xiaoqiang .
CLINICAL LABORATORY, 2019, 65 (10) :1789-1796