Biological predictors of chemotherapy-induced peripheral neuropathy (CIPN): MASCC neurological complications working group overview

被引：46

作者：

Chan, Alexandre ^{[1
,2
]}

Hertz, Daniel L. ^{[3
]}

Morales, Manuel ^{[4
]}

Adams, Elizabeth J. ^{[5
]}

Gordon, Sharon ^{[6
,7
]}

Tan, Chia Jie ^{[1
,2
]}

Staff, Nathan P. ^{[8
]}

Kamath, Jayesh ^{[9
]}

Oh, Jeong ^{[10
]}

Shinde, Shivani ^{[11
,12
]}

Pon, Doreen ^{[13
]}

Dixit, Niharkia ^{[14
,15
]}

D'Olimpio, James ^{[16
,17
]}

Dumitrescu, Cristina ^{[18
]}

Gobbo, Margherita ^{[19
]}

Kober, Kord ^{[14
,20
]}

Mayo, Samantha ^{[21
]}

Pang, Linda ^{[10
]}

Subbiah, Ishwaria ^{[10
]}

Beutler, Andreas S. ^{[8
]}

Peters, Katherine B. ^{[22
]}

Loprinzi, Charles ^{[8
]}

Lustberg, Maryam B. ^{[5
]}

机构：

[1] Natl Univ Singapore, Singapore, Singapore

[2] Natl Canc Ctr Singapore, Singapore, Singapore

[3] Univ Michigan, Ann Arbor, MI 48109 USA

[4] Univ Hosp Ntra, Santa Cruz De Tenerife, Spain

[5] Ohio State Univ, Comprehens Canc Ctr, Columbus, OH 43210 USA

[6] Univ Connecticut, Storrs, CT USA

[7] East Carolina Univ, Greenville, NC 27858 USA

[8] Mayo Clin, Rochester, FL USA

[9] Univ Connecticut, Hlth Ctr, Storrs, CT USA

[10] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[11] Univ Colorado, Boulder, CO 80309 USA

[12] VA Eastern Colorado Hlth Care Syst, Aurora, MS USA

[13] Western Univ Hlth Sci, Pomona, CA USA

[14] Univ Calif San Francisco, San Francisco, CA 94143 USA

[15] Zuckerberg San Francisco Gen Hosp, San Francisco, CA USA

[16] Northwell Canc Inst, New Hyde Pk, NY USA

[17] Zucker Sch Med Hofstra, 500 Hofstra Blvd, Hempstead, NY USA

[18] Marie Curie Hosp, London, England

[19] Univ Trieste, Trieste, Italy

[20] Helen Diller Comprehens Canc Ctr, San Francisco, CA USA

[21] Univ Toronto, Toronto, ON, Canada

[22] Preston Robert Tisch Brain Tumor Ctr, Durham, NC USA

来源：

SUPPORTIVE CARE IN CANCER | 2019年 / 27卷 / 10期

基金：

美国国家卫生研究院;

关键词：

Chemotherapy-induced peripheral neuropathy; CIPN; Neuropathy; GENOME-WIDE ASSOCIATION; CANCER-PATIENTS; GENETIC POLYMORPHISMS; MULTIPLE-MYELOMA; ELDERLY-PATIENTS; PACLITAXEL; OXALIPLATIN; BREAST; RISK; CISPLATIN;

D O I：

10.1007/s00520-019-04987-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating condition associated with a number of chemotherapeutic agents. Drugs commonly implicated in the development of CIPN include platinum agents, taxanes, vinca alkaloids, bortezomib, and thalidomide analogues. As a drug response can vary between individuals, it is hypothesized that an individual's specific genetic variants could impact the regulation of genes involved in drug pharmacokinetics, ion channel functioning, neurotoxicity, and DNA repair, which in turn affect CIPN development and severity. Variations of other molecular markers may also affect the incidence and severity of CIPN. Hence, the objective of this review was to summarize the known biological (molecular and genomic) predictors of CIPN and discuss the means to facilitate progress in this field.

引用

页码：3729 / 3737

页数：9

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