A novel cyclisation strategy for the synthesis of lactonamycin: A new route to highly functionalised heterocyclic rings

被引：15

作者：

Parsons, Philip J. ^{[1
]}

Board, Johnathan

Waters, Alexander J.

Hitchcock, Peter B.

Wakenhut, Florian

Walter, Daryl S.

机构：

[1] Univ Sussex, Sch Lifesci, Dept Chem, Brighton BN1 9QJ, E Sussex, England

[2] Pfizer Ltd, Sandwich CT13 9MJ, Kent, England

[3] GlaxoSmithKline Res & Dev Ltd, Harlow CM19 5AW, Essex, England

来源：

SYNLETT | 2006年 / 19期

基金：

英国工程与自然科学研究理事会;

关键词：

lactonamycin; furan; cascade; cyclisation; thermal;

D O I：

10.1055/s-2006-951542

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel thermal cascade reaction equivalent to the well-known [2+2+2] cycloaddition has been developed which is clean and reliable and does not involve the use of metal ions. This highly efficient method has been used to construct a model for the synthesis of the antibiotic lactonamycin. The utility of this new sequence for the formation of furans is also reported.

引用

页码：3243 / 3246

页数：4

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