Effect of surface roughness on initial responses of osteoblast-like cells on two types of zirconia

被引：132

作者：

Yamashita, Daisuke ^{[1
]}

Machigashira, Miho ^{[1
]}

Miyamoto, Motoharu ^{[1
]}

Takeuchi, Hironobu ^{[1
]}

Noguchi, Kazuyuki ^{[1
]}

Izumi, Yuichi ^{[2
]}

Bans, Seiji ^{[3
]}

机构：

[1] Kagoshima Univ, Dept Periodontol, Grad Sch Med & Dent Sci, Kagoshima 8908544, Japan

[2] Tokyo Med & Dent Univ, Grad Sch, Sect Periodontol, Dept Hard Tissue Engn,Div Biomatrix,Bunkyo Ku, Tokyo 1138501, Japan

[3] Kagoshima Univ, Dept Biomat Sci, Grad Sch Med & Dent Sci, Kagoshima 8908544, Japan

来源：

DENTAL MATERIALS JOURNAL | 2009年 / 28卷 / 04期

基金：

日本学术振兴会;

关键词：

Zirconia; Surface roughness; Osteoblast; MECHANICAL-PROPERTIES; SIGNAL-TRANSDUCTION; OPTIMAL AESTHETICS; DENTAL PROSTHESES; IMPLANT MATERIALS; TITANIUM; ADHESION; MULTICENTER; OSSEOINTEGRATION; PROLIFERATION;

D O I：

10.4012/dmj.28.461

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The aim of this study was to evaluate the effect of surface roughness on the initial attachment of mouse osteoblast-like cells on ceria-stabilized zirconia/alumina nanocomposite (NANOZR) and yttria-stabilized zirconia (3Y-TZP) in comparison to those on pure titanium (Ti) and alumina oxide (AO). Specimens with smooth and rough surfaces were prepared by grinding with diamond paper or by sandblasting, respectively. For four substrates examined, the number of attached cells on the rough surface specimens was significantly higher than that on the smooth surface specimens (p < 0.05). Integrin alpha(5) and beta(1) expression had a greater increase in rough surface specimens than in smooth surface specimens. Actin cytoskeleton organization was, however, similar for both smooth and rough surface specimens. NANOZR and 3Y-TZP produced good cell attachment, similar to Ti and AO. The overall results demonstrated that NANOZR and 3Y-TZP with rough surface could provide good initial cell responses, adequate for future implant usage.

引用

页码：461 / 470

页数：10

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