Time course of alterations in pre- and post-synaptic chemoreceptor function during developmental hyperoxia

被引：25
作者：
Donnelly, David F. [1 ]
Bavis, Ryan W. [2 ]
Kim, Insook [3 ]
Dbouk, Hassan A. [3 ]
Carroll, John L. [3 ]
机构：
[1] Yale Univ, Sch Med, Sect Resp Med, Dept Pediat, New Haven, CT 06520 USA
[2] Bates Coll, Dept Biol, Lewiston, ME 04240 USA
[3] Univ Arkansas Med Sci, Div Pulm Med, Dept Pediat, Little Rock, AR 72202 USA
来源：
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | 2009年 / 168卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Carotid body; Chemoreceptors; Hypoxia; Calcium; Hyperoxia; CAROTID-BODY CHEMORECEPTORS; HYPOXIC PHRENIC RESPONSES; SUDDEN-INFANT-DEATH; VENTILATORY RESPONSES; ADULT RATS; PERINATAL HYPEROXIA; IN-VITRO; BRONCHOPULMONARY DYSPLASIA; ARTERIAL CHEMORECEPTORS; INTERMITTENT HYPOXIA;
D O I：
10.1016/j.resp.2009.05.005
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Postnatal hyperoxia exposure reduces the carotid body response to acute hypoxia and produces a long-lasting impairment of the ventilatory response to hypoxia. The present work investigated the time course of pre- and post-synaptic alterations following exposure to hyperoxia (Fl(O2) = 0.6) for 1, 3, 5, 8 and 14 days (d) starting at postnatal day 7 (P7) as compared to age-matched controls. Hyperoxia exposure for I d enhanced the nerve response and glomus cell calcium response to acute hypoxia, but exposure for 3-5 d caused a significant reduction in both. Hypoxia-induced catecholamine release and nerve conduction velocity were significantly decreased by 5 d hyperoxia. We conclude that hyperoxia exerts pre-synaptic (glomus cell calcium and secretory responses) and post-synaptic (afferent nerve excitability) actions to initially enhance and then reduce the chemoreceptor response to acute hypoxia. The parallel changes in glomus cell calcium response and nerve response suggest causality between the two and that environmental hyperoxia can affect the coupling between acute hypoxia and glomus cell calcium regulation. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：189 / 197
页数：9
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