Neurological events associated with the infusion of cryopreserved bone marrow and/or peripheral blood progenitor cells

被引:78
作者
Hoyt, R [1 ]
Szer, J [1 ]
Grigg, A [1 ]
机构
[1] Royal Melbourne Hosp, Bone Marrow Transplant Serv, Dept Clin Haematol & Med Oncol, Melbourne, Vic 3050, Australia
关键词
DMSO; neurologic toxicity; transient global amnesia;
D O I
10.1038/sj.bmt.1702443
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Reports of neurological toxicity of cryopreserved stem cell infusion are infrequent, Three of 179 consecutive patients experienced significant neurological events in this context. Transient global amnesia developed following infusion in one patient and in the other two, cerebral infarction occurred. Profound hypotension, bradyarrhythmias or hypoxia were not associated with any of these episodes. These events may have been related to infused DMSO, which in the non-transplant setting has been associated with neurological toxicity and local infusion of which has resulted in acute vasospasm in animal models. These cases suggest that infusion of cryopreserved stem cells may result in cerebrovascular ischaemia.
引用
收藏
页码:1285 / 1287
页数:3
相关论文
共 8 条
[1]   Adverse events occurring during bone marrow or peripheral blood progenitor cell infusion: analysis of 126 cases [J].
Alessandrino, E ;
Bernasconi, P ;
Caldera, D ;
Colombo, A ;
Bonfichi, M ;
Malcovati, L ;
Klersy, C ;
Martinelli, G ;
Maiocchi, M ;
Pagnucco, G ;
Varettoni, M ;
Perotti, C ;
Bernasconi, C .
BONE MARROW TRANSPLANTATION, 1999, 23 (06) :533-537
[2]   Diffusion-weighted MRI characterizes the ischemic lesion in transient global amnesia [J].
Ay, H ;
Furie, KL ;
Yamada, K ;
Koroshetz, WJ .
NEUROLOGY, 1998, 51 (03) :901-903
[3]  
BOND GR, 1989, LANCET, V1, P1134
[4]  
Chaloupka JC, 1999, AM J NEURORADIOL, V20, P401
[5]  
DAVIS JM, 1990, BLOOD, V75, P781
[6]   THE ETIOLOGY OF TRANSIENT GLOBAL AMNESIA - A CASE-CONTROL STUDY OF 114 CASES WITH PROSPECTIVE FOLLOW-UP [J].
HODGES, JR ;
WARLOW, CP .
BRAIN, 1990, 113 :639-657
[7]  
STYLER MJ, 1992, BONE MARROW TRANSPL, V10, P435
[8]  
YELLOWLEES P, 1980, LANCET, V2, P1004