Total synthesis of isotopically labelled flavonoids, 2 -: 13C-labelled (±)-catechin from potassium [13C]cyanide

被引：0

作者：

Nay, B ^{[1
]}

Amaudinaud, V ^{[1
]}

Peyrat, JF ^{[1
]}

Nuhrich, A ^{[1
]}

Deffieux, G ^{[1
]}

Mérillon, JM ^{[1
]}

Vercauteren, J ^{[1
]}

机构：

[1] Univ Bordeaux 2, Fac Pharm, Lab Pharmacognosie, GESNIT, F-33076 Bordeaux, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 2000卷 / 07期

关键词：

flavonoids; catechin; isotopic labelling; carbon; 13; total synthesis; French paradox;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Racemic 4-[C-13]catechin 14 has been synthesized in ten steps starting from potassium [C-13]cyanide. The intermediate chalcone 9 was formed by acylation of the benzylated phloroglucinol 7 with the caffeic acid synthon 6, using the trifluoroacetic mixed anhydride. The flavonoid skeleton was then obtained by previously described reactions such as the reduction of chalcone 9 and dihydroxylation of flavene 11. Such [C-13]-labelled polyphenols should prove to be useful tools for human biological investigations.

引用

页码：1279 / 1283

页数：5

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