Vi capsular polysaccharide: Synthesis, virulence, and application

被引：43

作者：

Hu, Xiaomei ^{[1
]}

Chen, Zhijin ^{[1
]}

Xiong, Kun ^{[1
]}

Wang, Jing ^{[1
]}

Rao, Xiancai ^{[1
]}

Cong, Yanguang ^{[1
]}

机构：

[1] Third Mil Med Univ, Dept Microbiol, Chongqing 400038, Peoples R China

来源：

CRITICAL REVIEWS IN MICROBIOLOGY | 2017年 / 43卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Vi; capsular polysaccharide; Salmonella; virulence; vaccine; ENTERICA SEROVAR TYPHI; INTESTINAL EPITHELIAL-CELLS; ESCHERICHIA-COLI K1; SALMONELLA-PARATYPHI-C; ATTENUATED IN-VIVO; SEROTYPE TYPHI; PATHOGENICITY ISLAND; SIGNAL-TRANSDUCTION; ANTIGEN-EXPRESSION; IMMUNE-RESPONSES;

D O I：

10.1080/1040841X.2016.1249335

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vi capsular polysaccharide, a linear homopolymer of alpha-1,4-linked N-acetylgalactosaminuronate, is characteristically produced by Salmonella enterica serovar Typhi. The Vi capsule covers the surface of the producing bacteria and serves as an virulence factor via inhibition of complement-mediated killing and promoting resistance against phagocytosis. Furthermore, Vi also represents a predominant protective antigen and plays a key role in the development of vaccines against typhoid fever. Herein, we reviewed the latest advances associated with the Vi polysaccharide, from its synthesis and transport within bacterial cells, mechanisms involved in virulence, immunological characteristics, and applications in vaccine, as well as its purification and detection methods.

引用

页码：440 / 452

页数：13

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